Flt-3/Flk-2/CD135 Products

Description

FMS-like tyrosine kinase 3 (Flt‑3), also named Fetal liver kinase-2 (Flk-2) is a member of the class III receptor tyrosine kinase subfamily and plays a role in normal hematopoiesis. The classs III RTK family, which includes Flt-3, KIT, SCFR and CSF1R share a conserved architecture of an extracellular domain (ECD) with five immunoglobulin-like domains, a transmembrane domain and an intracellular region with a juxtamembrane domain and two intracellular tyrosine-kinase domains. The ECD of human Flt-3 shares 85% amino acid sequence identity with mouse Flt-3. Flt-3 expression has been detected in various tissues, including placenta, gonads, and tissues of nervous and hematopoietic origin (1). Among hematopoietic cells, the expression of Flt-3 was found to be restricted to the highly enriched stem/progenitor cell populations (2). The ligand for Flt-3 has been identified as Flt-3 ligand (Flt-3L or FL) and activation of Flt-3 signaling mediates cell survival, cell proliferation, and differentiation of hematopoietic progenitor cells (1). Flt-3 has been implicated in several diseases, including autoimmune diseases, such as rheumatoid arthritis, as well as in acute myeloid leukemia where around one-third of patients carry a Flt-3 mutation which drives the disease and is correlated with poor prognosis (3-5). Our Avi-tag Biotinylated Flt‑3 features biotinylation at a single site contained within the Avi-tag, a unique 15 amino acid peptide. Protein orientation will be uniform when bound to streptavidin-coated surface due to the precise control of biotinylation and the rest of the protein is unchanged so there is no interference in the protein's bioactivity.

Bioinformatics

Uniprot	P36888.2
Product By Gene ID	2322
Alternate Names	CD135 antigen CD135 EC 2.7.10 fetal liver kinase 2 FL cytokine receptor FLK2 Flk-2 FLT3 receptor tyrosine kinase Flt3 Flt-3 Fms-like tyrosine kinase 3 fms-related tyrosine kinase 3 growth factor receptor tyrosine kinase type III Stem cell tyrosine kinase 1 STK-1 STK1EC 2.7.10.1 Tyrosine-protein kinase receptor FLT3