FMOD, also known as Fibromodulin, is a 376 amino acid protein that is 43 kDa, affects the rate of fibrils formation and may have a primary role in collagen fibrillogenesis and regulation of TGF-beta activities by sequestering TGF-beta into the extracellular matrix. Current research is being performed on several diseases and disorders including refractive error, chronic lymphocytic leukemia, myopia, osteoarthritis, arthritis, cleft lip/palate, age related macular degeneration, pseudoachondroplasia, periodontitis, mantle cell lymphoma, chondrodysplasia, diabetic nephropathy, vaginitis, leiomyoma, essential hypertension, atherosclerosis, hypochondrogenesis, and Kniest dysplasia. This protein has also shown an interaction with TGFB1, TGFB2 and TGFB3 in Metalloproteases in connective tissue degradation, metabolism, MPS VI - Maroteaux-Lamy syndrome, disease, keratan sulfate/keratin metabolism, and MPS IIIA - Sanfilippo syndrome A pathways.
|Product By Gene ID
- Keratan sulfate proteoglycan fibromodulin
- fibromodulin proteoglycan
- Collagen-binding 59 kDa protein
- SLRR2EKSPG fibromodulin