Fc epsilon RI Products

Description

The IgE receptor plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma. The allergic response occurs when 2 or more high-affinity IgE receptors are crosslinked via IgE molecules that in turn are bound to an allergen (antigen) molecule. A perturbation occurs that brings about the release of histamine and proteases from the granules in the cytoplasm of the mast cell and leads to the synthesis of prostaglandins and leukotrienes--potent effectors of the hypersensitivity response. The IgE receptor consists of 3 subunits: alpha, beta (MIM 147138), and gamma (MIM 147139); only the alpha subunit is glycosylated.[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Bioinformatics

Product By Gene ID	2205
Alternate Names	alpha polypeptide Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide Fc-epsilon RI-alpha FcERI high affinity immunoglobulin epsilon receptor alpha-subunit high affinity immunoglobulin epsilon receptor subunit alpha high-affinity, of mast cells, alpha polypeptide

Research Areas for Fc epsilon RI

Find related products by research area and learn more about each of the different research areas below.

Asthma
Immunology