FBXW2 Products

Description

F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. A large family of mammalian F-box proteins has recently been identified and classified into three groups based on the presence of either the WD-40 repeats, the leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. The FBXW2 gene product, the second identified member of the F-box gene family, contains multiple WD-40 repeats.

Bioinformatics

Entrez	26190 Human
Uniprot	AAH18738 Human NM_012164 Human NP_036296. Human Q9UKT8 Human
Product By Gene ID	26190
Alternate Names	F-box and WD repeat domain containing 2 F-box and WD-40 domain protein 2 F-box and WD-40 domain-containing protein 2 F-box/WD repeat-containing protein 2 FBW2Fwd2 FWD2 Md6 MGC117371 Protein MD6