FBXW2 Products

Description

F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. A large family of mammalian F-box proteins has recently been identified and classified into three groups based on the presence of either the WD-40 repeats, the leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. The FBXW2 gene product, the second identified member of the F-box gene family, contains multiple WD-40 repeats.

Bioinformatics

Entrez	26190 Human
Uniprot	NM_012164 Human Q9UKT8 Human AAH18738 Human NP_036296. Human
Product By Gene ID	26190
Alternate Names	F-box and WD-40 domain-containing protein 2 Protein MD6 F-box and WD-40 domain protein 2 FWD2 Md6 F-box/WD repeat-containing protein 2 FBW2Fwd2 MGC117371 F-box and WD repeat domain containing 2

Diseases related to FBXW2

Discover more about diseases related to FBXW2.

Arthritis
Small Cell Carcinoma Of Lung
Lung Neoplasms
Autoimmune Reaction
Neoplasms
Rheumatoid Arthritis
Autoimmune Diseases
Carcinoma

Pathways for FBXW2

View related products by pathway and learn more about each of the pathways below.

Rna Interference
Glial Cell Differentiation
Gland Development
Cell Cycle
Cell Differentiation
Parathyroid Gland Development

PTMs for FBXW2

Learn more about PTMs related to FBXW2.

Ubiquitination

Bioinformatics Tool for FBXW2

Discover related pathways, diseases and genes to FBXW2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.