F4/80 Products

Antibodies

Description

F4/80, aka EMR1 (EGF-like module-containing mucin-like hormone receptor-like 1), is a 160 kDa cell surface glycoprotein as part of the EGF-TM7 protein family. F4/80 is known for its mouse and rat reactivity, while EMR1 is known for its human validation; F4/80 shares 68% amino acid similarity with human EMR1. F4/80 expressed in various macrophages including Kupffer, Langerhans, Microglia cells of skin, connective tissue, heart, reproductive, and neuroendocrine systems, but the expressions vary in macrophage type, developmental processes, and maturation state. F4/80 is also found on APCs in Peyer’s patches and dendritic cells in central nervous system. Even though F4/80’s ligands and biological functionalities have not been determined, recent studies suggest F4/80 role in the generation of efferent CD8+ Treg cell induction. F4/80 is well-characterized and extensively studied membrane protein best known for its mature mouse macrophage and microglial marker.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Mouse
Product By Gene ID 13733
Alternate Names
  • Mouse EMR1
  • Rat EMR1
  • EGF-TM7
  • lymphocyte antigen 71
  • TM7LN3
  • EGF-like module-containing mucin-like hormone receptor-like 1
  • F4/80
  • Gpf480
  • cell surface glycoprotein F4/80
  • EGF-like module receptor 1
  • EMR1 hormone receptor
  • Ly71
  • DD7A5-7
  • EGF-like module containing, mucin-like, hormone receptor-like sequence 1

Research Areas for F4/80

Find related products by research area and learn more about each of the different research areas below.

Immune System Diseases
Immunology
Innate Immunity

Bioinformatics Tool for F4/80

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