ErbB4/Her4 Products

Description

erbB4/HER4 is a receptor tyrosine kinase that belongs to the human epidermal growth factor receptor (EGFR) family. erbB4/HER4 is most predominantly expressed in several breast carcinoma cell lines, and in normal skeletal muscle, heart, pituitary, brain, and cerebellum (1). erbB4/HER4 is activated by neuregulins (NRG), betacellulin (BTC), and heparin-binding EGF-like growth factor (2). Neuregulins regulate the expression of ligand- and voltage-gated channels in neurons and skeletal muscle by the activation of ErbB 1-4. The erbB4/HER4 receptor is unique among these receptors because its C-terminal tail binds to a protein motif known as the PDZ domain (3).

Bioinformatics

Product By Gene ID	2066
Alternate Names	avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4 EC 2.7.10 EC 2.7.10.1 ErbB4 HER4 HER4MGC138404 p180erbB4 Proto-oncogene-like protein c-ErbB-4 receptor tyrosine-protein kinase erbB-4 Tyrosine kinase-type cell surface receptor HER4 v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)

Research Areas for ErbB4/Her4

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Cancer
Protein Kinase
Tumor Suppressors

Related ErbB4/Her4 Blog Posts

Check out the latest blog posts on ErbB4/Her4.

Hypoxia-Dependent CAR Stabilizing Construct in T cells Improves Solid Tumor Targeting and Efficacy By Victoria Osinski, PhDDespite advances in the development of cancer immunotherapies, those specifically targeting tumors still remains limited. Currently, there is great interest in utilizing chimeric antigen rece...    Read more.

Read more ErbB4/Her4 related blogs.