ErbB4/Her4 Products

Description

erbB4/HER4 is a receptor tyrosine kinase that belongs to the human epidermal growth factor receptor (EGFR) family. erbB4/HER4 is most predominantly expressed in several breast carcinoma cell lines, and in normal skeletal muscle, heart, pituitary, brain, and cerebellum (1). erbB4/HER4 is activated by neuregulins (NRG), betacellulin (BTC), and heparin-binding EGF-like growth factor (2). Neuregulins regulate the expression of ligand- and voltage-gated channels in neurons and skeletal muscle by the activation of ErbB 1-4. The erbB4/HER4 receptor is unique among these receptors because its C-terminal tail binds to a protein motif known as the PDZ domain (3).

Bioinformatics

Entrez	13867 Mouse 13869 Mouse 2066 Human 29496 Rat 59323 Rat
Uniprot	NM_001042599 Human NP_005226 Human Q15303 Human
Product By Gene ID	2066
Alternate Names	avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4 EC 2.7.10 EC 2.7.10.1 HER4MGC138404 p180erbB4 Proto-oncogene-like protein c-ErbB-4 receptor tyrosine-protein kinase erbB-4 Tyrosine kinase-type cell surface receptor HER4 v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)

Research Areas for ErbB4/Her4

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Cancer
Phospho-Specific
Protein Kinase
Tumor Suppressors

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