ErbB2/Her2 Products

Antibodies
ErbB2/Her2 Antibody [Unconjug ...
ErbB2/Her2 Antibody [Unconjugated]
AF1129
Species: Hu
Applications: WB, Flow, IHC, InhibCellGro
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
ErbB2/Her2 [p Tyr1248] Antibo ...
ErbB2/Her2 [p Tyr1248] Antibody
NB100-81960
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
ELISA Kits
ErbB2/Her2 ELISA Kit
ErbB2/Her2 ELISA Kit
NBP1-84823
Species: Hu
Applications: ELISA
ErbB2/Her2 ELISA Kit [Biotin] ...
ErbB2/Her2 ELISA Kit [Biotin]
KA1070
Species: Hu
Lysates
ErbB2/Her2 Overexpression Lys ...
ErbB2/Her2 Overexpression Lysate (...
NBL1-10314
Applications: WB
Proteins
ErbB2/Her2 Recombinant Protei ...
ErbB2/Her2 Recombinant Protein
H00002064-P01
Species: Hu
Applications: WB, ELISA, PA, PAGE
ErbB2/Her2 Recombinant Protei ...
ErbB2/Her2 Recombinant Protein
NBP1-94702
Species: Hu
Applications: ELISA
ErbB2/Her2 Partial Recombinan ...
ErbB2/Her2 Partial Recombinant Pro...
H00002064-Q01
Species: Hu
Applications: WB, ELISA, PA
RNAi
ErbB2/Her2 RNAi
ErbB2/Her2 RNAi
H00002064-R05
Species: Hu
Applications: RNAi, RNAi SP
ErbB2/Her2 RNAi
ErbB2/Her2 RNAi
H00002064-R06
Species: Hu
Applications: RNAi, RNAi SP

Description

ErbB2/HER2 is one of the four members of the ErbB receptor family of transmembrane receptor-like tyrosine kinases (1). The kinase activity of ErbB2 can be activated without ligand if it is overexpressed, and by association with other ErbB proteins (2). Overexpression of ErbB2 is detected in almost 40% of human breast cancers (3). Binding of c-Cbl ubiquitin ligase to Tyr1112 of ErbB2 leads to poly-ubiquitination of ErbB2 and enhances its degradation (4). ErbB2 is one of the major targets for the treatment of breast cancer and other carcinomas.

Bioinformatics

Entrez Human
Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Product By Gene ID 2064
Alternate Names
  • MLN 19
  • EC 2.7.10
  • Tyrosine kinase-type cell surface receptor HER2
  • CD340 antigen
  • Proto-oncogene Neu
  • MLN19
  • Proto-oncogene c-ErbB-2
  • receptor tyrosine-protein kinase erbB-2
  • Metastatic lymph node gene 19 protein
  • neuroblastoma/glioblastoma derived oncogene homolog
  • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2(neuro/glioblastoma derived oncogene homolog)
  • herstatin
  • HER-2
  • c-erb B2/neu protein
  • CD340
  • NGLTKR1
  • NEUHER-2/neu
  • HER2EC 2.7.10.1
  • p185erbB2
  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastomaderived oncogene homolog (avian)

Research Areas for ErbB2/Her2

Find related products by research area and learn more about each of the different research areas below.

Breast Cancer
Cancer
Cellular Markers
Core ESC-Like Genes
Phospho-Specific
Protein Kinase
Stem Cell Markers
Tumor Suppressors

Bioinformatics Tool for ErbB2/Her2

Discover related pathways, diseases and genes to ErbB2/Her2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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