Epsin-2 Products

Antibodies
Epsin-2 Antibody (1G3)
Epsin-2 Antibody (1G3)
Species: Hu, Mk, Pm
Applications: WB, Flow, ICC/IF, IHC, IHC-P
Host: Mouse Monoclonal
Epsin-2 Antibody
Epsin-2 Antibody
NBP2-13965
Species: Hu
Applications: ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Epsin-2 Antibody
Epsin-2 Antibody
NBP2-16359
Species: Hu
Applications: WB
Host: Rabbit Polyclonal
Lysates
Epsin-2 Overexpression Lysate ...
Epsin-2 Overexpression Lysate (Nat...
NBL1-10298
Applications: WB
Epsin-2 Overexpression Lysate ...
Epsin-2 Overexpression Lysate (Nat...
NBP2-05424
Applications: WB
Proteins
Epsin-2 Partial Recombinant P ...
Epsin-2 Partial Recombinant Protein
H00022905-Q01
Species: Hu
Applications: WB, ELISA, PA
Epsin-2 Recombinant Protein A ...
Epsin-2 Recombinant Protein Antigen
NBP2-13965PEP
Species: Hu
Applications: AC
RNAi
Epsin-2 RNAi
Epsin-2 RNAi
H00022905-R01
Species: Hu
Epsin-2 RNAi
Epsin-2 RNAi
H00022905-R03
Species: Hu
Epsin-2 RNAi
Epsin-2 RNAi
H00022905-R02
Species: Hu

Description

Elucidation of the mechanism by which receptor tyrosine kinases (RTKs) modulate cellular physiology in response to stimuli is critical to the understanding of growth regulation. Miscues in RTK signaling pathways can result in cellular transformation and ultimately in cancer. Two novel EGF receptor substrates designated EGF-receptor pathway substrates 8 and 15, or Eps8 and Eps15, have been described. Epsin is a 90 kDa binding partner to Eps15. Both epsin and Eps15 have an ubiquitous tissue distribution but are concentrated in presynaptic nerve terminals specialized for the Clathrin-mediated endocytosis of synaptic vesicles. Disruption of epsin function blocks Clathrinmediated endocytosis. Epsin along with its binding partner Eps15 is proposed to be involved in the assistance of Clathrin coat rearrangement during Clathrin coated pit invagination. Epsin 2 and epsin 2a are also associated with Clathrin-mediated endocytosis and are enriched in the brain in the peri-Golgi region.

Bioinformatics

Entrez Human
Rat
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 22905
Alternate Names
  • epsin-2
  • EPS-15-interacting protein 2
  • Eps15 binding protein
  • KIAA1065EHB21
  • epsin 2

Diseases related to Epsin-2

Discover more about diseases related to Epsin-2.

Cholangiocarcinoma
Hiv Infections
Neurodegenerative Disorders
Tissue Adhesions
Diarrhea
Parkinson Disease

PTMs for Epsin-2

Learn more about PTMs related to Epsin-2.

Ubiquitination
Phosphorylation

Bioinformatics Tool for Epsin-2

Discover related pathways, diseases and genes to Epsin-2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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