Ephrin-B3 Products

Description

EFNB3, a member of the ephrin gene family, is important in brain development as well as in its maintenance. Moreover, since levels of EFNB3 expression were particularly high in several forebrain subregions compared to other brain subregions, it may play a pivotal role in forebrain function. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH Receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.

Bioinformatics

Entrez	1949 Human
Uniprot	Q15768
Product By Gene ID	1949
Alternate Names	EFL-6 Efnb3 Elk-L3 EPH-related receptor tyrosine kinase ligand 8 Ephrin B3 EphrinB3 Ephrin-B3 Epl8 EPLG8EPH-related receptor transmembrane ligand ELK-L3 LERK-8 LERK8EFL6 NLERK-2

Related Ephrin-B3 Blog Posts

Check out the latest blog posts on Ephrin-B3.

Identifying tumoral and stromal transcriptomes that underlie tumor plasticity and stromal neuroinflammatory response in brain metastasis By Jamshed Arslan, Pharm. D., PhD. Cancers in the brain often come from tumors elsewhere in the body. Several adaptive mechanisms influence brain metastasis, such as blood brain barrier leakage that can be induced by ...    Read more.

Read more Ephrin-B3 related blogs.