eIF4G1 Products

Description

eIF4G1 (eukaryotic translation Initiation Factor 4 Gamma 1) is a component of the protein complex eIF-4 which is involved in the recognition of the mRNA cap ATP-dependent unwinding of the terminal secondary structure and recruitment of mRNA to the ribosome. eIF4G plays a critical role in protein expression and is at the center of a complex regulatory network. Together with the cap-binding protein eIF4E, it recruits the small ribosomal subunit to the end of mRNA and promotes the assembly of a functional translation initiation complex which scans along the mRNA to the translation start codon. Human eIF4G contains three consecutive HEAT domains, as well as long unstructured regions involved in multiple protein-protein interactions. The interactions of eIF4G1 with other factors are largely unknown.

Bioinformatics

Entrez	1981 Human 287986 Rat
Uniprot	AAH07788 Human AAH07788.1 Human NP_004944 Human NP_886553 Human P04637 Human Q04637 Human
Product By Gene ID	1981
Alternate Names	DKFZp686A1451 EIF4F eIF-4G 1 eIF-4G1 EIF-4G1 eIF-4-gamma 1 EIF4-gamma EIF4GI EIF4Gp220 eucaryotic translation initiation factor 4G eukaryotic translation initiation factor 4 gamma 1 eukaryotic translation initiation factor 4 gamma, 1 P220

Research Areas for eIF4G1

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