EGLN2/PHD1 Products

Antibodies
EGLN2/PHD1 Antibody
EGLN2/PHD1 Antibody
NB100-310
Species: Hu, Mu, Rt
Applications: WB, Simple Western, EM, ICC/IF, IHC, IHC-P, IP, ICC
Host: Rabbit Polyclonal
EGLN2/PHD1 Antibody
EGLN2/PHD1 Antibody
AF6394
Species: Hu
Applications: WB, IP
Host: Sheep Polyclonal
EGLN2/PHD1 Antibody (2G3)
EGLN2/PHD1 Antibody (2G3)
H00112398-M01
Species: Hu
Applications: WB, ELISA
Host: Mouse Monoclonal
Lysates
EGLN2/PHD1 Overexpression Lys ...
EGLN2/PHD1 Overexpression Lysate (...
NBL1-10154
Applications: WB
EGLN2/PHD1 Overexpression Lys ...
EGLN2/PHD1 Overexpression Lysate (...
NBL1-10155
Applications: WB
Proteins
EGLN2/PHD1 Recombinant Protei ...
EGLN2/PHD1 Recombinant Protein
H00112398-P01
Species: Hu
Applications: WB, ELISA, PA
RNAi
EGLN2/PHD1 RNAi
EGLN2/PHD1 RNAi
H00112398-R01
Species: Hu
EGLN2/PHD1 RNAi
EGLN2/PHD1 RNAi
H00112398-R02
Species: Hu
EGLN2/PHD1 RNAi
EGLN2/PHD1 RNAi
H00112398-R03
Species: Hu

Description

HIF prolyl hydroxylase 1 (HPH-3 or EGLN2) is a prolyl hydroxylase that modifies HIF-alpha. Classic prolyl hydroxylases are found in the endoplasmic reticulum and modify collagen, whereas HIF is an intracellular protein and the HPH sites do not resemble those modifying collagen. HIF is a transcriptional complex that plays a critical role in oxygen homeostasis. HPH is an essential component of the pathway through which cells sense oxygen. In the presence of oxygen, HPHs convert specific prolyl residues in HIF-alpha to hydroxyproline, leading to HIF-alpha destruction. Low oxygen levels, sensed at the cellular level, cause the HIF conversion to be reduced so that HIF is stable and there is increased angiogenesis.

Bioinformatics

Uniprot Human
Human
Human
Human
Human
Product By Gene ID 112398
Alternate Names
  • HIF-prolyl hydroxylase 1
  • HPH-1
  • EC 1.14.11
  • HIF-PH1
  • EC 1.14.11.-
  • EIT6
  • egl nine homolog 2
  • Prolyl hydroxylase domain-containing protein 1
  • FLJ95603
  • Hypoxia-inducible factor prolyl hydroxylase 1
  • DKFZp434E026
  • Estrogen-induced tag 6
  • HIFPH1 EGL nine (C.elegans) homolog 2
  • PHD1
  • HPH-3
  • egl nine homolog 2 (C. elegans)

Research Areas for EGLN2/PHD1

Find related products by research area and learn more about each of the different research areas below.

Cancer
Hypoxia
Signal Transduction

PTMs for EGLN2/PHD1

Learn more about PTMs related to EGLN2/PHD1.

Hydroxylation
Phosphorylation
Methylation
Ubiquitination

Bioinformatics Tool for EGLN2/PHD1

Discover related pathways, diseases and genes to EGLN2/PHD1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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