EBP Products

Description

EBP is an integral membrane protein of the endoplasmic reticulum. It is a high affinity binding protein for the antiischemic phenylalkylamine Ca2+ antagonist [3H]emopamil and the photoaffinity label [3H]azidopamil. It is similar to sigma receptors and may be a member of a superfamily of high affinity drug-binding proteins in the endoplasmic reticulum of different tissues. These aromatic amino acid residues have been suggested to be involved in the drug transport by the P-glycoprotein. Mutations in EBP gene cause Chondrodysplasia punctata 2 (CDPX2; also known as Conradi-Hunermann syndrome).Emopamil-binding protein (EBP) is an integral membrane protein of the endoplasmic reticulum. It is a high affinity binding protein for the antiischemic phenylalkylamine Ca2+ antagonist [3H]emopamil and the photoaffinity label [3H]azidopamil. It is similar to sigma receptors and may be a member of a superfamily of high affinity drug-binding proteins in the endoplasmic reticulum of different tissues. EBP shares structural features with bacterial and eukaryontic drug transporting proteins. It has four putative transmembrane segments and contains two conserved glutamate residues which may be involved in the transport of cationic amphiphilics. Another prominent feature of EBP is its high content of aromatic amino acid residues (>23%) in its transmembrane segments. These aromatic amino acid residues have been suggested to be involved in the drug transport by the P-glycoprotein. Mutations in this gene cause Chondrodysplasia punctata 2 (CDPX2; also known as Conradi-Hunermann syndrome).

Bioinformatics

Uniprot	Q15125 Human
Product By Gene ID	10682
Alternate Names	3-beta-hydroxysteroid-Delta(8) CDPX2 Cholestenol Delta-isomerase CPX3-beta-hydroxysteroid-delta-8 CPXDX-linked dominant (Happle syndrome) D8-D7 sterol isomerase Delta(7)-isomerase Delta(8)-Delta(7) sterol isomerase delta-7-isomerase EBP EC 5.3.3.5 emopamil binding protein (sterol isomerase) Emopamil-binding protein sterol 8-isomerase

Research Areas for EBP

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cardiovascular Biology
Signal Transduction