Species: Hu, Mu, Rt
Applications: ICC/IF
Host: Rabbit Polyclonal
Species: Hu
Applications: IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
DPH5 encodes a component of the diphthamide synthesis pathway. Diphthamide is a post-translationally modified histidine residue found only on translation elongation factor 2. It is conserved from archaebacteria to humans, and is targeted by diphtheria toxin and Pseudomonas exotoxin A to halt cellular protein synthesis. The yeast and Chinese hamster homologs of this protein catalyze the trimethylation of the histidine residue on elongation factor 2, resulting in a diphthine moiety that is subsequently amidated to yield diphthamide. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
Human
|
| Product By Gene ID |
51611 |
| Alternate Names |
- CGI-30
- Diphthamide biosynthesis methyltransferase
- diphthine synthase
- DPH5 homolog (S. cerevisiae)
- EC 2.1.1.98
- HSPC143
- MGC61450
- NPD015
- protein x 0011
|
Research Areas for DPH5
Find related products by research area and learn more about each of the different research areas below.
Lipid and Metabolism
