DOK2 Products

Description

Docking proteins interact with receptor tyrosine kinases and mediate particular biological responses using signal transduction. DOK2 acts as a multiple docking protein downstream of receptor or non-receptor tyrosine kinases. By this mechanism it acts to negatively regulate signal transduction and cell proliferation controlled by cytokines in a feedback loop. DOK2 is highly expressed in cells and tissues of hematopoietic origin as well as in lung. Expression of bcr/abl induces additional tyrosine phosphorylation of the DOK1 and DOK2 proteins and their association with Ras-GAP. Thus, it is suspected that DOK association regulates GAP activity toward Ras and that the DOK proteins serve as mediators of bcr-abl signaling. The role of DOK proteins in bcr-abl regulation may also be implicated in chronic myelogenous leukemia (CML), which is characterized by a Philadelphia chromosome translocation t(9;22). Such a mutation would result in a p210-bcr/abl chimeric protein-tyrosine kinase which has been found in many CML cases.

Bioinformatics

Entrez	13449 Mouse 9046 Human
Uniprot	NM_003974 Human O60496 Human
Product By Gene ID	9046
Alternate Names	docking protein 2 docking protein 2, 56kD docking protein 2, 56kDa Dok-2 Downstream of tyrosine kinase 2 p56(dok-2) p56DOK P56DOK p56dok-2

Research Areas for DOK2

Find related products by research area and learn more about each of the different research areas below.

Phospho-Specific
Signal Transduction