DOK2 Products

DOK2 Overexpression Lysate
DOK2 Overexpression Lysate
Species: Hu
Applications: WB
Recombinant Human DOK2 Protei ...
Recombinant Human DOK2 Protein
Species: Hu
Applications: WB, ELISA, PA, AP
DOK2 Recombinant Protein Anti ...
DOK2 Recombinant Protein Antigen
Species: Hu
Applications: AC


Docking proteins interact with receptor tyrosine kinases and mediate particular biological responses using signal transduction. DOK2 acts as a multiple docking protein downstream of receptor or non-receptor tyrosine kinases. By this mechanism it acts to negatively regulate signal transduction and cell proliferation controlled by cytokines in a feedback loop. DOK2 is highly expressed in cells and tissues of hematopoietic origin as well as in lung. Expression of bcr/abl induces additional tyrosine phosphorylation of the DOK1 and DOK2 proteins and their association with Ras-GAP. Thus, it is suspected that DOK association regulates GAP activity toward Ras and that the DOK proteins serve as mediators of bcr-abl signaling. The role of DOK proteins in bcr-abl regulation may also be implicated in chronic myelogenous leukemia (CML), which is characterized by a Philadelphia chromosome translocation t(9;22). Such a mutation would result in a p210-bcr/abl chimeric protein-tyrosine kinase which has been found in many CML cases.


Entrez Human
Uniprot Human
Product By Gene ID 9046
Alternate Names
  • Dok-2
  • P56DOK
  • p56(dok-2)
  • p56DOK
  • Downstream of tyrosine kinase 2
  • docking protein 2
  • p56dok-2
  • docking protein 2, 56kD
  • docking protein 2, 56kDa

Research Areas for DOK2

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Signal Transduction

PTMs for DOK2

Learn more about PTMs related to DOK2.


Bioinformatics Tool for DOK2

Discover related pathways, diseases and genes to DOK2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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