DOK2 Products

Antibodies
DOK2 Antibody (1A4)
DOK2 Antibody (1A4)
NBP2-00948
Species: Hu
Applications: WB, Flow, ICC/IF
Host: Mouse Monoclonal
DOK2 Antibody
DOK2 Antibody
NBP1-35777
Species: Hu
Applications: IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
DOK2 Overexpression Lysate (N ...
DOK2 Overexpression Lysate (Native)
NBL1-09978
Applications: WB
Proteins
Recombinant Human DOK2 Protei ...
Recombinant Human DOK2 Protein
H00009046-P01
Species: Hu
Applications: WB, ELISA, PA

Description

Docking proteins interact with receptor tyrosine kinases and mediate particular biological responses using signal transduction. DOK2 acts as a multiple docking protein downstream of receptor or non-receptor tyrosine kinases. By this mechanism it acts to negatively regulate signal transduction and cell proliferation controlled by cytokines in a feedback loop. DOK2 is highly expressed in cells and tissues of hematopoietic origin as well as in lung. Expression of bcr/abl induces additional tyrosine phosphorylation of the DOK1 and DOK2 proteins and their association with Ras-GAP. Thus, it is suspected that DOK association regulates GAP activity toward Ras and that the DOK proteins serve as mediators of bcr-abl signaling. The role of DOK proteins in bcr-abl regulation may also be implicated in chronic myelogenous leukemia (CML), which is characterized by a Philadelphia chromosome translocation t(9;22). Such a mutation would result in a p210-bcr/abl chimeric protein-tyrosine kinase which has been found in many CML cases.

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Product By Gene ID 9046
Alternate Names
  • Dok-2
  • P56DOK
  • p56(dok-2)
  • p56DOK
  • Downstream of tyrosine kinase 2
  • docking protein 2
  • p56dok-2
  • docking protein 2, 56kD
  • docking protein 2, 56kDa

Research Areas for DOK2

Find related products by research area and learn more about each of the different research areas below.

Phospho-Specific
Signal Transduction

PTMs for DOK2

Learn more about PTMs related to DOK2.

Phosphorylation
Methylation

Bioinformatics Tool for DOK2

Discover related pathways, diseases and genes to DOK2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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