DNAM-1/CD226 Products

Description

CD226 is a 65kD type I transmembrane glycoprotein, known as DNAM-1 (DNAX accessory molecule-1), PTA1(platelet and T cell activation antigen 1), or TLiSA1 (T lineage-specific activation antigen 1 antigen). It belongs to immunoglobulin superfamily containing 2 Ig-like domains, is expressed on majority of T lymphocytes, NK cells, monocytes, platelets, and a subset of B cells, activated endothelial cells. DNAM-1 is also expressed on CD8+ (but not CD8-) dendritic cells in mouse model. CD226 is an adhesion molecule involved in CTL and NK cell-mediated cytotoxicity. It has been identified that CD155 (poliovirus receptor, PVR) and CD112 (nectin-2, PRR-2) are CD226 ligands. DX11 antibody is able to inhibit CTL and NK cell-mediated cytotoxicity, and to block T cell cytokine production.

Bioinformatics

Entrez	10666 Human
Uniprot	NM_006566 Human NP_006557 Human Q15762 Human
Product By Gene ID	10666
Alternate Names	CD226 antigenplatelet and T cell activation antigen 1 CD226 molecule DNAM1adhesion glycoprotein DNAM-1DNAX accessory molecule-1 DNAX accessory molecule 1 PTA1 T lineage-specific activation antigen 1 antigen TLiSA1