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FAB2408A) and either (A) Mouse Anti-Human DNAM-1/CD226 Monoclonal Antibody (Catalog # MAB666) or (B) Mouse IgG1Isotype Control (Catalog # MAB002) followed by Phycoerythrin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # F0102B)." class="big_lightbox" target="_blank">
666-DN) to Biotinylated Recombinant Human CD155/PVR Fc Chimera Avi-tag (AVI9174). The Neutralization Dose (ND50) for this effect is typically 0.300-6.00 µg/mL." class="big_lightbox" target="_blank">
666-DN), immobilized onto a microplate, supports the adhesion of the COLO 205 human colorectal adenocarcinoma cell line in a dose-dependent manner (orange line). Adhesion elicited by Recombinant Human DNAM-1/CD226 Fc Chimera (20 µg/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Human DNAM-1/ CD226 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF666). The ND50 is typically 0.5-1.5 µg/mL." class="big_lightbox" target="_blank">
9174-CD) is immobilized at 2 µg/mL, Recombinant Human DNAM-1/CD226 Fc Chimera Avi-tag (Catalog # AVI666) binds with an ED50 of 0.07-0.42 µg/mL." class="big_lightbox" target="_blank">
CD226 is a 65kD type I transmembrane glycoprotein, known as DNAM-1 (DNAX accessory molecule-1), PTA1(platelet and T cell activation antigen 1), or TLiSA1 (T lineage-specific activation antigen 1 antigen). It belongs to immunoglobulin superfamily containing 2 Ig-like domains, is expressed on majority of T lymphocytes, NK cells, monocytes, platelets, and a subset of B cells, activated endothelial cells. DNAM-1 is also expressed on CD8+ (but not CD8-) dendritic cells in mouse model. CD226 is an adhesion molecule involved in CTL and NK cell-mediated cytotoxicity. It has been identified that CD155 (poliovirus receptor, PVR) and CD112 (nectin-2, PRR-2) are CD226 ligands. DX11 antibody is able to inhibit CTL and NK cell-mediated cytotoxicity, and to block T cell cytokine production.
![Neutralization DNAM-1/CD226 Antibody [Unconjugated]](http://images.novusbio.com/images/antibody/DNAM-1_AF666_Block_Neutralize_8941.jpg)
![N/A DNAM-1/CD226 [Biotin]](http://images.novusbio.com/fullsize/dy666-05_human-dnam-1-cd226-duoset-elisa-5-plate-3182021134227.jpg)
![Binding Activity DNAM-1/CD226 [Biotin]](http://images.novusbio.com/images/protein/DNAM1_AVI9298_2673.jpg)
![Bioactivity DNAM-1/CD226 [Unconjugated]](http://images.novusbio.com/fullsize/protein/DNAM1_4436DN_1290.jpg)
![Binding Activity DNAM-1/CD226 [Biotin]](http://images.novusbio.com/images/protein/DNAM1_AVI666_2770.jpg)
![Flow Cytometry DNAM-1/CD226 Antibody (102511) [Unconjugated]](http://images.novusbio.com/images/antibody/DNAM1_MAB666_Flow_Cytometry_19202.jpg)
![Neutralization DNAM-1/CD226 Antibody (102511) [Unconjugated]](http://images.novusbio.com/images/antibody/mab666_human-dnam-1-cd226-mab-clone-102511-neutralization-59202414937.jpg)
![SDS-Page DNAM-1/CD226 [Biotin]](http://images.novusbio.com/fullsize/protein/DNAM1_AVI9298_2500.jpg)
![SDS-Page DNAM-1/CD226 [Biotin]](http://images.novusbio.com/fullsize/protein/DNAM1_AVI666_2649.jpg)
