Species: Hu, Mu
Applications: WB, Func, ICC/IF, IHC, IP
Host: Mouse Monoclonal
Species: Hu
Applications: WB
Host: Rabbit Polyclonal
Species: Hu, Mu
Applications: WB, ELISA, ICC/IF
Host: Rabbit Polyclonal
Species: Hu
Applications: AC
Description
DNA ligase 1 catalyzes the joining of double-stranded DNA ends during replication, recombination, and repair. Structurally, DNA ligase 1 is toroidal and encircles nicked DNA substrates. The 9-1-1 complex, a DNA damage checkpoint complex, has been reported to associate with DNA ligase 1 and stimulate ligase activity. Mutations in DNA ligase 1 result in immunodeficiency and increased sensitivity to DNA-damaging agents.
Bioinformatics
| Product By Gene ID |
3978 |
| Alternate Names |
- DNA ligase 1
- DNA Ligase I
- EC 6.5.1.1
- ligase I, DNA, ATP-dependent
- MGC117397
- MGC130025
- Polydeoxyribonucleotide synthase [ATP] 1
- polydeoxyribonucleotide synthase ATP 1
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Related DNA Ligase I Blog Posts
Check out the latest blog posts on DNA Ligase I.
Using PCNA as an Antibody Marker
PCNA antibodies are useful biomarkers in DNA repair studies. PCNA is one of several proteins essential for the completion of nucleotide excision repair, a multi-stage process involving 20 - 30 proteins, and an important factor in repairing damage and ... Read more.
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Read more DNA Ligase I related blogs.
