DNA Ligase I Products

Description

DNA ligase 1 catalyzes the joining of double-stranded DNA ends during replication, recombination, and repair. Structurally, DNA ligase 1 is toroidal and encircles nicked DNA substrates. The 9-1-1 complex, a DNA damage checkpoint complex, has been reported to associate with DNA ligase 1 and stimulate ligase activity. Mutations in DNA ligase 1 result in immunodeficiency and increased sensitivity to DNA-damaging agents.

Bioinformatics

Entrez	3978 Human 81513 Rat
Uniprot	NP_000225 Human NP_000225.1 Human P18858 Human
Product By Gene ID	3978
Alternate Names	DNA ligase 1 DNA ligase I EC 6.5.1.1 ligase I, DNA, ATP-dependent MGC117397 MGC130025 Polydeoxyribonucleotide synthase [ATP] 1 polydeoxyribonucleotide synthase ATP 1

Research Areas for DNA Ligase I

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Base Excision Repair
Cancer
DNA Repair
Nucleotide Excision Repair
Tumor Suppressors

Related DNA Ligase I Blog Posts

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Using PCNA as an Antibody Marker PCNA antibodies are useful biomarkers in DNA repair studies. PCNA is one of several proteins essential for the completion of nucleotide excision repair, a multi-stage process involving 20 - 30 proteins, and an important factor in repairing damage and ...    Read more.

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