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DDX19B, also known as ATP-dependent RNA helicase DDX19B, consists of four isoforms of sizes 53.9 kDa, 50.5 kDa, 41.8 kDa, and 51 kDa and is involved in exporting mRNA from the nucleus by remodeling the ribonucleoprotein particles instead of unwinding RNA duplexes. Current research is linking the protein to diseases and disorders such as apraxia, pneumonia, Werner syndrome, malaria, and locked-in syndrome. The protein interacts in protein transport pathways with PRKAG1, CDC5L, RAE1, UBA5, and SNW1.