DDB1 Products

Antibodies
DDB1 Antibody
DDB1 Antibody
NBP1-33061
Species: Hu, Mu, Rt
Applications: WB, IB, ICC/IF, IHC, IHC-P, IP
Host: Rabbit Polyclonal
DDB1 Antibody
DDB1 Antibody
NBP2-27207
Species: Hu, Mu, Rt, Po, Bv, Ca, Eq, Fe, Other, Pm
Applications: WB, Flow
Host: Rabbit Polyclonal
DDB1 Antibody
DDB1 Antibody
NBP1-02782
Species: Hu
Applications: WB, ELISA, IHC, IHC-P, IP
Host: Rabbit Polyclonal
Proteins
DDB1 Recombinant Protein
DDB1 Recombinant Protein
H00001642-P01
Species: Hu
Applications: WB, ELISA, PA
DDB1 Partial Recombinant Prot ...
DDB1 Partial Recombinant Protein
H00001642-Q01
Species: Hu
Applications: WB, ELISA, PA
DDB1 Recombinant Protein Anti ...
DDB1 Recombinant Protein Antigen
NBP2-38538PEP
Species: Hu
Applications: AC
RNAi
DDB1 RNAi
DDB1 RNAi
H00001642-R01
Species: Hu

Description

Damage specific DNA binding protein (DDB) functions in nucleotide-excision repair. Its defective activity causes the repair defect in the patients with xeroderma pigmentosum complementation group E (XPE). To test whether the DNA-repair defect in the subset of XPE patients that lack DNA damage-binding activity is caused by a defect in DDB, purified human DDB protein was injected into XPE cells. The injected DDB protein stimulated DNA repair to normal levels in those strains that lacked the DDB activity but did not stimulate repair in cells from XPE patients that contained the activity. These results provided direct evidence that defective DDB activity causes the repair defect in a subset of XPE patients and establishes a role for this activity in nucleotide excision repair in vivo. It remains for mutation analysis to demonstrate whether the defect in XPE patients is in the DDB1 gene or the DDB2 gene.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Product By Gene ID 1642
Alternate Names
  • UV-damaged DNA-binding factor
  • XPCe
  • HBV X-associated protein 1
  • DDBa
  • DNA damage-binding protein a
  • DNA damage-binding protein 1
  • DDB p127 subunit
  • XPCE
  • XPE-BF
  • UV-DDB1
  • XAP1
  • DDBA
  • XAP-1
  • damage-specific DNA binding protein 1 (127kD)
  • Xeroderma pigmentosum group E-complementing protein
  • XPE-binding factor
  • Damage-specific DNA-binding protein 1
  • UV-DDB 1
  • XPE
  • UV-damaged DNA-binding protein 1
  • damage-specific DNA binding protein 1, 127kDa

Research Areas for DDB1

Find related products by research area and learn more about each of the different research areas below.

DNA Repair
Nucleotide Excision Repair

PTMs for DDB1

Learn more about PTMs related to DDB1.

Ubiquitination
Phosphorylation
Methylation
Reduction
Cleavage

Bioinformatics Tool for DDB1

Discover related pathways, diseases and genes to DDB1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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