DDB1 Products

Description

Damage specific DNA binding protein (DDB) functions in nucleotide-excision repair. Its defective activity causes the repair defect in the patients with xeroderma pigmentosum complementation group E (XPE). To test whether the DNA-repair defect in the subset of XPE patients that lack DNA damage-binding activity is caused by a defect in DDB, purified human DDB protein was injected into XPE cells. The injected DDB protein stimulated DNA repair to normal levels in those strains that lacked the DDB activity but did not stimulate repair in cells from XPE patients that contained the activity. These results provided direct evidence that defective DDB activity causes the repair defect in a subset of XPE patients and establishes a role for this activity in nucleotide excision repair in vivo. It remains for mutation analysis to demonstrate whether the defect in XPE patients is in the DDB1 gene or the DDB2 gene.

Bioinformatics

Entrez	13194 Mouse 1642 Human 64470 Rat
Uniprot	NP_001914 Human Q16531 Human
Product By Gene ID	1642
Alternate Names	damage-specific DNA binding protein 1 (127kD) damage-specific DNA binding protein 1, 127kDa Damage-specific DNA-binding protein 1 DDB p127 subunit DDBa DDBA DNA damage-binding protein 1 DNA damage-binding protein a HBV X-associated protein 1 UV-damaged DNA-binding factor UV-damaged DNA-binding protein 1 UV-DDB 1 UV-DDB1 XAP1 XAP-1 Xeroderma pigmentosum group E-complementing protein XPCe XPCE XPE XPE-BF XPE-binding factor

Research Areas for DDB1

Find related products by research area and learn more about each of the different research areas below.

DNA Repair
Nucleotide Excision Repair