Cytohesin-1 Products

Description

The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This gene is highly expressed in natural killer and peripheral T cells, and regulates the adhesiveness of integrins at the plasma membrane of lymphocytes. The encoded protein is 83% homologous to that of CYTH2. [provided by RefSeq]

Bioinformatics

Entrez	9267 Human
Uniprot	NP_004753.1 Human
Product By Gene ID	9267
Alternate Names	B2-1 CYTH1 cytoadhesin 1 cytohesin 1 Cytohesin1 Cytohesin-1 D17S811ECYTOHESIN-1 FLJ34050 FLJ41900 homolog of secretory protein SEC7 PH, SEC7 and coiled-coil domain-containing protein 1 pleckstrin homology, Sec7 and coiled-coil domains 1 PSCD1 SEC7 homolog B2-1 SEC7

Research Areas for Cytohesin-1

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Membrane Trafficking and Chaperones