Cytochrome P450 2E1 Products

Description

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer.

Bioinformatics

Entrez	1571 Human
Uniprot	NP_000764.1 Human
Product By Gene ID	1571
Alternate Names	4-nitrophenol 2-hydroxylase CPE1 CYP2Ecytochrome P450 2E1 CYPIIE1 cytochrome P450, family 2, subfamily E, polypeptide 1 cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1 Cytochrome P450-J EC 1.14.13.- EC 1.14.13.n7 EC 1.14.14.1 flavoprotein-linked monooxygenase microsomal monooxygenase P450C2E P450-J xenobiotic monooxygenase

Research Areas for Cytochrome P450 2E1

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Lipid and Metabolism