CYP7B1 Products

Description

P450 enzymes constitute a family of monooxygenase enzymes that are involved in the metabolism of a wide array of endogenous and xenobiotic compounds including cholesterol. CYP8B1 moderates the ratio of cholic acid over chenodeoxycholic acid to control the solubility of cholesterol. P450 cholesterol 7-hydroxylase, CYP7A1, is the rate limiting enzyme of bile acid synthesis in the liver, and its expression is mediated by the bile acid receptor FXR. CYP27A1 catalyzes vitamin D3 25-hydroxylation and is localized to the mitochondria in kidney and liver. CYP7B1 (oxysterol 7-alpha-hydroxylase) functions as an enzyme in the alternate bile acid synthesis pathway. Specifically, CYP7B1 metabolizes 25- and 27-hydroxycholesterol. The gene encoding human CYP7B1 maps to chromosome 8q21.3. Mutations in the CYP7B1 gene may cause a metabolic defect in bile acid synthesis characterized by elevated urinary bile acid excretion, severe cholestasis, cirrhosis and liver synthetic failure.

Bioinformatics

Entrez	9420 Human
Uniprot	NP_004811 Human NP_004811.1 Human O75881 Human
Product By Gene ID	9420
Alternate Names	SPG5A EC 1.14.13.100 CBAS3 oxysterol 7alpha-hydroxylase Oxysterol 7-alpha-hydroxylase CP7B Cytochrome P450 7B1 cytochrome P450, subfamily VIIB (oxysterol 7 alpha-hydroxylase), polypeptide 1,25-hydroxycholesterol 7-alpha-hydroxylase spastic paraplegia 5A (autosomal recessive) cytochrome P450, family 7, subfamily B, polypeptide 1

Diseases related to CYP7B1

Discover more about diseases related to CYP7B1.

Spastic Paraplegia, Hereditary
Paraplegia
Spastic Paraplegia
Cholestasis
Neoplasms
Liver Diseases
Inflammation
Neurodegenerative Disorders
Malignant Neoplasms
Liver Carcinoma
Muscle Spasticity
Malignant Neoplasm Of Prostate
Hypercholesterolemia
Hepatitis
Prostatic Neoplasms
Liver Cirrhosis
Weakness
Carcinoma
Intrahepatic Cholestasis

Pathways for CYP7B1

View related products by pathway and learn more about each of the pathways below.

Pathogenesis
Cholesterol Homeostasis
Immune Response
Excretion
Secretion
Gallstone Formation
Lipid Homeostasis
Transport
Inflammatory Response
Tissue Development
Reverse Transcription
Cognition
Cell Proliferation
Circadian Rhythm
Methylation
Hepatocyte Differentiation
Fibroblast Proliferation
Adaptive Immune Response
Regulation Of Gene Expression
Intestinal Absorption

PTMs for CYP7B1

Learn more about PTMs related to CYP7B1.

Hydroxylation
Methylation
Reduction
Sumoylation
Acetylation
Oxidation

Bioinformatics Tool for CYP7B1

Discover related pathways, diseases and genes to CYP7B1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.