CYP7B1 Products

Antibodies
CYP7B1 Antibody
CYP7B1 Antibody
NBP2-31092
Species: Hu
Applications: PEP-ELISA
Host: Goat Polyclonal
CYP7B1 Antibody
CYP7B1 Antibody
H00009420-A01
Species: Hu, Mu, Rt
Applications: WB, ELISA
Host: Mouse Polyclonal
CYP7B1 Antibody (2B11)
CYP7B1 Antibody (2B11)
H00009420-M06
Species: Hu
Applications: WB, ELISA, IHC, IHC-P
Host: Mouse Monoclonal
Lysates
CYP7B1 Overexpression Lysate ...
CYP7B1 Overexpression Lysate (Dena...
H00009420-T02
Species: Hu
Applications: WB
CYP7B1 Overexpression Lysate ...
CYP7B1 Overexpression Lysate (Native)
NBP2-07820
Applications: WB
Proteins
CYP7B1 Partial Recombinant Pr ...
CYP7B1 Partial Recombinant Protein
H00009420-Q01
Species: Hu
Applications: WB, ELISA, PA
CYP7B1 Recombinant Protein
CYP7B1 Recombinant Protein
H00009420-P01
Species: Hu
Applications: WB, ELISA, PA
CYP7B1 Recombinant Protein An ...
CYP7B1 Recombinant Protein Antigen
NBP1-87013PEP
Species: Hu
Applications: AC
RNAi
CYP7B1 RNAi
CYP7B1 RNAi
H00009420-R01
Species: Hu

Description

P450 enzymes constitute a family of monooxygenase enzymes that are involved in the metabolism of a wide array of endogenous and xenobiotic compounds including cholesterol. CYP8B1 moderates the ratio of cholic acid over chenodeoxycholic acid to control the solubility of cholesterol. P450 cholesterol 7-hydroxylase, CYP7A1, is the rate limiting enzyme of bile acid synthesis in the liver, and its expression is mediated by the bile acid receptor FXR. CYP27A1 catalyzes vitamin D3 25-hydroxylation and is localized to the mitochondria in kidney and liver. CYP7B1 (oxysterol 7-alpha-hydroxylase) functions as an enzyme in the alternate bile acid synthesis pathway. Specifically, CYP7B1 metabolizes 25- and 27-hydroxycholesterol. The gene encoding human CYP7B1 maps to chromosome 8q21.3. Mutations in the CYP7B1 gene may cause a metabolic defect in bile acid synthesis characterized by elevated urinary bile acid excretion, severe cholestasis, cirrhosis and liver synthetic failure.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Product By Gene ID 9420
Alternate Names
  • SPG5A
  • EC 1.14.13.100
  • CBAS3
  • oxysterol 7alpha-hydroxylase
  • Oxysterol 7-alpha-hydroxylase
  • CP7B
  • Cytochrome P450 7B1
  • cytochrome P450, subfamily VIIB (oxysterol 7 alpha-hydroxylase), polypeptide 1,25-hydroxycholesterol 7-alpha-hydroxylase
  • spastic paraplegia 5A (autosomal recessive)
  • cytochrome P450, family 7, subfamily B, polypeptide 1

PTMs for CYP7B1

Learn more about PTMs related to CYP7B1.

Hydroxylation
Methylation
Reduction
Sumoylation
Acetylation
Oxidation

Bioinformatics Tool for CYP7B1

Discover related pathways, diseases and genes to CYP7B1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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