CTPS2 Products

Description

The protein encoded by the CTPS2 gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamineto glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play animportant role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA.Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein.Thus, this protein is an attractive target for selective chemotherapy. Three alternatively spliced transcript variantsencoding the same protein have been described for this gene. (provided by RefSeq)

Bioinformatics

Entrez	56474 Human
Uniprot	AAH34986 Human NM_175859 Human NP_001137474 Human NP_062831 Human NP_062831.3 Human
Product By Gene ID	56474
Alternate Names	CTP synthase 2 CTP synthase II CTP synthetase 2 CTP synthetase isoform CTP synthetase type 2 cytidine 5'-triphosphate synthetase 2 DKFZp686C17207 EC 6.3.4.2 FLJ43358 MGC32997 UTP--ammonia ligase 2 UTP-ammonia ligase

Research Areas for CTPS2

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Stem Cell Markers