CTPS2 Products

Description

The protein encoded by the CTPS2 gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamineto glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play animportant role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA.Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein.Thus, this protein is an attractive target for selective chemotherapy. Three alternatively spliced transcript variantsencoding the same protein have been described for this gene. (provided by RefSeq)

Bioinformatics

Entrez	56474 Human
Uniprot	AAH34986 Human NM_175859 Human NP_001137474 Human NP_062831 Human NP_062831.3 Human
Product By Gene ID	56474
Alternate Names	CTP synthase 2 CTP synthase II CTP synthetase 2 CTP synthetase isoform CTP synthetase type 2 cytidine 5'-triphosphate synthetase 2 DKFZp686C17207 EC 6.3.4.2 FLJ43358 MGC32997 UTP--ammonia ligase 2 UTP-ammonia ligase

Diseases related to CTPS2

Discover more about diseases related to CTPS2.

Malignant Neoplasms
Cataract
Colorectal Neoplasms
Colorectal Cancer
Stage Iii Colorectal Cancer

Pathways for CTPS2

View related products by pathway and learn more about each of the pathways below.

Transport
Cell Cycle
Activation Of Protein Kinase A Activity

Research Areas for CTPS2

Find related products by research area and learn more about each of the different research areas below.

Stem Cell Markers

PTMs for CTPS2

Learn more about PTMs related to CTPS2.

Phosphorylation

Bioinformatics Tool for CTPS2

Discover related pathways, diseases and genes to CTPS2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.