Contactin-1 Products

Description

Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth.; SUBUNIT: Monomer. Interacts with CNTNAP1 in cis form. Binds to the carbonic-anhydrase like domain of protein-tyrosine phosphatase zeta. Interacts with NOTCH1 and TNR.

Bioinformatics

Entrez	117258 Rat 1272 Human 12805 Mouse
Uniprot	NM_001843 Human NP_778203 Human Q12860 Human Q63198 Rat
Product By Gene ID	1272
Alternate Names	contactin 1 contactin-1 F3 Glycoprotein gp135 GP135 Neural cell surface protein F3