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Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth.; SUBUNIT: Monomer. Interacts with CNTNAP1 in cis form. Binds to the carbonic-anhydrase like domain of protein-tyrosine phosphatase zeta. Interacts with NOTCH1 and TNR.
![Immunohistochemistry Contactin-1 Antibody [Unconjugated]](http://images.novusbio.com/fullsize/antibody/Contactin-1_AF904_Immunohistochemistry_6914.jpg)
![Western Blot Contactin-1 Antibody [Unconjugated]](http://images.novusbio.com/fullsize/antibody/Contactin-1_AF904_Western_Blot_5941.jpg)
![Simple Western Contactin-1 Antibody [Unconjugated]](http://images.novusbio.com/fullsize/antibody/Contactin1_AF904_Simple_Western_20110.jpg)
![Neutralization Contactin-1 Antibody [Unconjugated]](http://images.novusbio.com/fullsize/antibody/Contactin-1_AF904_Block_Neutralize_8982.jpg)
![Immunohistochemistry Contactin-1 Antibody [Unconjugated]](http://images.novusbio.com/fullsize/af904_human-mouse-rat-contactin-1-affinity-purified-polyclonal-ab-8120255531691.jpg)
![Immunohistochemistry Contactin-1 Antibody [Unconjugated]](http://images.novusbio.com/fullsize/af904_human-mouse-rat-contactin-1-affinity-purified-polyclonal-ab-812025555347.jpg)
![Western Blot Contactin-1 Antibody [Unconjugated]](http://images.novusbio.com/fullsize/af904_human-mouse-rat-contactin-1-affinity-purified-polyclonal-ab-western-blot-12122025811817.jpg)
![Western Blot Contactin-1 Antibody [Unconjugated]](http://images.novusbio.com/fullsize/antibody/Contactin-1_AF7549_Western_Blot_12303.jpg)
![Immunohistochemistry Contactin-1 Antibody [Unconjugated]](http://images.novusbio.com/fullsize/antibody/Contactin1_AF7549_Immunohistochemistry_19787.jpg)
![Western Blot Contactin-1 Antibody (2332B) [Unconjugated]](http://images.novusbio.com/fullsize/antibody/Contactin1_MAB9041_Western_Blot_22894.jpg)
![Bioactivity Contactin-1 [Unconjugated]](http://images.novusbio.com/fullsize/protein/Contactin1_9665CN_1748.jpg)