Hu, Mu, RtApplications:
WB, Simple Western, IHC, B/NHost:
Species: Hu, Mu, Rt
Applications: WB, IHC
Host: Sheep Polyclonal
Host: Rabbit Monoclonal
Binding Activity, Bioactivity
Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth.; SUBUNIT: Monomer. Interacts with CNTNAP1 in cis form. Binds to the carbonic-anhydrase like domain of protein-tyrosine phosphatase zeta. Interacts with NOTCH1 and TNR.
PTMs for Contactin-1
Learn more about PTMs related to Contactin-1.Phosphorylation
Bioinformatics Tool for Contactin-1
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