Hu, Mu, Rt, Bv, MaApplications:
WB, ELISA, IHC, IHC-P, IPHost:
Species: Hu, Mu, Rt, Bv
Applications: WB, ELISA, ICC/IF, IHC, IHC-Fr, IHC-P, ICC
Host: Goat Polyclonal
ELISA, ICC/IF, IHC, IHC-PHost:
Applications: WB, ELISA, IHC, IHC-P
Applications: WB, ELISA, IHC
Collagen IV is well suited to detect extracellular matrix proteins in normal as well as disease state tissues. Disruption of tissue organization is the hallmark of neoplasia. Malignant lesions can be distinguished from benign by examining the breakdown of basement membranes and loss of 3-dimensional architecture. Malignant cells are presumed to use matrix metalloproteases to degrade barriers created by the extracellular matrix which then allows metastasis to occur. Collagenases, stomelysins and gelatinases can collectively degrade all of the various components of the extracellular matrix, including fibrillar and non-fibrillar collagens and basement membrane glycoproteins.
|Product By Gene ID
- collagen alpha-1(IV) chain
- EC 188.8.131.52
- COL4A1 NC1 domain
- EC 3.4.23
- alpha-1 chain
- collagen IV, alpha-1 polypeptide
- collagen, type IV, alpha 1
Bioinformatics Tool for Collagen IV alpha 1
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|Epithelial-Mesenchymal Transition (EMT) Markers
Epithelial-Mesenchymal Transition (EMT) is the trans-differentiation of stationary epithelial cells into motile mesenchymal cells. During EMT, epithelial cells lose their junctions and apical-basal polarity, reorganize their cytoskeleton, undergo a... Read more.