Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, COMET, mIF
Host: Rabbit Monoclonal
Species: Hu
Applications: IHC, mIF
Host: Mouse Monoclonal
Species: Hu
Applications: WB, IHC
Host: Sheep Polyclonal
Species: Hu
Applications: ELISA
Species: Rt
Applications: ELISA
Species: Mu
Applications: ELISA
Species: Hu
Applications: Bioactivity
Description
Collagen IV is a major constituent of the basement membranes along with laminins, proteoglycans and enactins. It is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. It can form insoluble fibers with high tensile strength. Collagen IV is useful in detecting the loss of parts of basement membranes in carcinomas. This antibody is well suited to detect extracellular matrix proteins in normal as well as disease state tissues. Disruption of tissue organization is the hallmark of neoplasia. Malignant lesions can be distinguished from benign by examining the breakdown of basement membranes and loss of 3-dimensional architecture. Malignant cells are presumed to use matrix metalloproteases to degrade barriers created by the extracellular matrix which then allows metastasis to occur. Collagenases, stomelysins and gelatinases can collectively degrade all of the various components of the extracellular matrix, including fibrillar and non-fibrillar collagens and basement membrane glycoproteins.
Bioinformatics
| Entrez |
Mouse
|
| Product By Gene ID |
1282 |
| Alternate Names |
- alpha-1 chain
- Arresten
- COL4A1 NC1 domain
- COL4A1
- collagen alpha-1(IV) chain
- Collagen IV alpha 1
- collagen IV, alpha-1 polypeptide
- collagen, type IV, alpha 1
- Collagen-4
- EC 3.4.23
- EC 6.3.1.2
|
![Multiplex Immunofluorescence Collagen IV alpha 1 Antibody (1106301) [Unconjugated]](http://images.novusbio.com/fullsize/antibody/mab11758_human-collagen-iv-alpha-1-mab-clone-1106301-multiplex-immunofluorescence-101120251334.png)
![Western Blot Collagen IV alpha 1 Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/Collagen_IV_alpha_1_AF6308_Western_Blot_10060.jpg)
![Binding Activity Collagen IV alpha 1 [Unconjugated]](http://images.novusbio.com/fullsize/11597-cl_recombinant-human-collagen-iv-alpha-1-his-tag-protein-cf-binding-activity-2092024102745.jpg)
![Multiplex Immunofluorescence Collagen IV alpha 1 Antibody (1106301) [Unconjugated]](http://images.novusbio.com/fullsize/antibody/mab11758_human-collagen-iv-alpha-1-mab-clone-1106301-multiplex-immunofluorescence-511202591957.png)
![Multiplex Immunofluorescence Collagen IV alpha 1 Antibody (1106301) [Unconjugated]](http://images.novusbio.com/fullsize/antibody/mab11758_human-collagen-iv-alpha-1-mab-clone-1106301-multiplex-immunofluorescence-1011202513415.png)
![Immunohistochemistry Collagen IV alpha 1 Antibody (1106301) [Unconjugated]](http://images.novusbio.com/fullsize/antibody/mab11758_human-collagen-iv-alpha-1-mab-clone-1106301-immunohistochemistry-2710202511558.jpg)
![Immunohistochemistry Collagen IV alpha 1 Antibody (1106301) [Unconjugated]](http://images.novusbio.com/fullsize/antibody/mab11758_human-collagen-iv-alpha-1-mab-clone-1106301-immunohistochemistry-27102025115646.jpg)
![Immunohistochemistry Collagen IV alpha 1 Antibody (1106301) [Unconjugated]](http://images.novusbio.com/fullsize/antibody/mab11758_human-collagen-iv-alpha-1-mab-clone-1106301-immunohistochemistry-2710202511569.jpg)
![Immunohistochemistry Collagen IV alpha 1 Antibody [Unconjugated]](http://images.novusbio.com/fullsize/af6308_human-collagen-iv-alpha-1-affinity-purified-polyclonal-ab-immunohistochemistry-264202394623..jpg)
![SDS-PAGE Collagen IV alpha 1 [Unconjugated]](http://images.novusbio.com/fullsize/11597-cl_recombinant-human-collagen-iv-alpha-1-his-tag-protein-cf-sds-page-2092024104923.jpg)