Collagen IV alpha 1 Products

Description

Collagen IV is well suited to detect extracellular matrix proteins in normal as well as disease state tissues. Disruption of tissue organization is the hallmark of neoplasia. Malignant lesions can be distinguished from benign by examining the breakdown of basement membranes and loss of 3-dimensional architecture. Malignant cells are presumed to use matrix metalloproteases to degrade barriers created by the extracellular matrix which then allows metastasis to occur. Collagenases, stomelysins and gelatinases can collectively degrade all of the various components of the extracellular matrix, including fibrillar and non-fibrillar collagens and basement membrane glycoproteins.

Bioinformatics

Entrez	1282 Human 12826 Mouse 290905 Rat
Uniprot	P02462 Human P02463 Mouse
Product By Gene ID	1282
Alternate Names	alpha-1 chain arresten COL4A1 NC1 domain collagen alpha-1(IV) chain collagen IV, alpha-1 polypeptide collagen, type IV, alpha 1 Collagen-4 EC 3.4.23 EC 6.3.1.2

Research Areas for Collagen IV alpha 1

Find related products by research area and learn more about each of the different research areas below.

Cytoskeleton Markers
Extracellular Matrix
Stem Cell Markers

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Epithelial-Mesenchymal Transition (EMT) Markers Epithelial-Mesenchymal Transition (EMT) is the trans-differentiation of stationary epithelial cells into motile mesenchymal cells. During EMT, epithelial cells lose their junctions and apical-basal polarity, reorganize their cytoskeleton, undergo a...    Read more.

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