cIAP-1/HIAP-2 Products

Antibodies
cIAP-1/HIAP-2 Antibody [Uncon ...
cIAP-1/HIAP-2 Antibody [Unconjugated]
AF8181
Species: Hu
Applications: WB, IHC
Host: Goat Polyclonal
cIAP-1/HIAP-2 Antibody
cIAP-1/HIAP-2 Antibody
NBP2-27190
Species: Hu, Mu, Rt, Ca, Other
Applications: WB, IHC-Fr, IHC-P, IP
Host: Rabbit Polyclonal
cIAP-1/HIAP-2 Antibody
cIAP-1/HIAP-2 Antibody
NB100-56128
Species: Hu
Applications: WB, IHC, IHC-P, IP
Host: Rabbit Polyclonal
Lysates
cIAP-1/HIAP-2 Overexpression ...
cIAP-1/HIAP-2 Overexpression Lysat...
H00000329-T02
Species: Hu
Applications: WB
Proteins
cIAP-1/HIAP-2 Recombinant Pro ...
cIAP-1/HIAP-2 Recombinant Protein
H00000329-P01
Species: Hu
Applications: WB, ELISA, PA
cIAP-1/HIAP-2 Recombinant Pro ...
cIAP-1/HIAP-2 Recombinant Protein ...
NBP1-90133PEP
Species: Hu
Applications: AC
cIAP-1/HIAP-2 Peptide
cIAP-1/HIAP-2 Peptide
NBP1-77193PEP
Species: Hu
Applications: AC
RNAi
cIAP-1/HIAP-2 RNAi
cIAP-1/HIAP-2 RNAi
H00000329-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

cIAP1 (HIAP2, MIHB) is a member of the family of inhibitor of apoptosis proteins (IAP). IAPs suppress mitochondria-dependent and -independent apoptosis by binding to and inhibiting caspases through their BIR domains (reviewed in Liston et al, 2003; Wright and Duckett, 2005). Resistance towards apoptosis is a hallmark of cancer cells, and overexpression of IAPs can contribute to the development of cancer though inhibiting apoptosis. In addition to at least one BIR domain, some IAP members also have a RING-type finger motif at their carboxyl-terminal. The RING finger domain of several IAPs, including cIAP2, have E3 ubiquitin ligase activity and target the degradation of Smac/DIABLO through ubqiuitination. Smac/DIABLO is a death inducer and functions by inhibiting IAP-caspase interactions, thereby promoting apoptosis. Degradation of cell death inducers like Smac/DIABLO is thought to be a conserved mechanism by which IAPs enhance their anti-apoptotic activity, thereby promoting cell survival. The IAPs, including cIAP1, have widespread tissue protein expression, with expression levels and subcellular localization patterns differing depending on the cell lineage (see Vischioni et al. 2005 for a comprehensive study). This antibody recognizes cIAP1, human cIAP1 is a 618 amino acid protein.

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Human
Product By Gene ID 329
Alternate Names
  • hIAP2
  • RING finger protein 48
  • hIAP-2
  • IAP homolog B
  • IAP2
  • IAP-2
  • C-IAP1
  • Inhibitor of apoptosis protein 2
  • NFR2-TRAF signalling complex protein
  • cIAP1
  • baculoviral IAP repeat-containing protein 2
  • c-IAP1
  • apoptosis inhibitor 1
  • baculoviral IAP repeat-containing 2
  • API1Hiap-2
  • RNF48hiap-2
  • MIHBHIAP2
  • TNFR2-TRAF-signaling complex protein 2
  • baculoviral IAP repeat containing 2

Research Areas for cIAP-1/HIAP-2

Find related products by research area and learn more about each of the different research areas below.

Apoptosis

PTMs for cIAP-1/HIAP-2

Learn more about PTMs related to cIAP-1/HIAP-2.

Phosphorylation
Cleavage
Ubiquitination
Sumoylation
Dephosphorylation
Methylation

Bioinformatics Tool for cIAP-1/HIAP-2

Discover related pathways, diseases and genes to cIAP-1/HIAP-2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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Related cIAP-1/HIAP-2 Blog Posts

Check out the latest blog posts on cIAP-1/HIAP-2.
cIAP1 - An apoptotic regulator with implications in drug resistant cancers
Cellular inhibitor of apoptosis protein-1 (cIAP-1) is an anti-apoptotic protein that is able to bind to caspases and inhibit their activity. Additionally cIAP-1 contains a RING domain with E3 ubiquitin ligase activity that is able to mediate the r...    Read more.
Read more cIAP-1/HIAP-2 related blogs.