CHMP4A Products

Description

CHMP4A (charged MVB protein 4A) is one of the three isoforms of CHMP4, the human equivalent of yeast Snf7 (so CHMP4A is also referred to as hSnf7-1). It is a component of the ESCRT-III (endosomal sorting complex required for transport III) complex. The ESCRT complexes mediate membrane budding away from the cytosol and cleavage of membrane necks (membrane fission) from the cytosolic face; hence, they are key in processes such as the formation of MVBs (multivesicular bodies), enveloped virus budding, and membrane abscission in cytokinesis. Not all types of ESCRT complexes, or proteins within those complexes, are necessary for all of these functions. For instance, research into the requirements of ESCRT-III proteins in HIV-1 budding has revealed that CHMP1 and CHMP3 proteins are not essential for this process; at least one member of each of the CHMP2 and CHMP4 families are required; within these families there is some functional redundancy; within the CHMP4 family, the relative importance and abundance of the isoforms is 4B > 4A > 4C; and the absence of CHMP4A or 4B prevents the budding process from progressing to completion.

Bioinformatics

Entrez	29082 Human
Uniprot	AAH10893 Human AAH10893.2 Human NP_054888 Human Q9BY43 Human
Product By Gene ID	29082
Alternate Names	C14orf123 charged multivesicular body protein 4a CHMP4 CHMP4a CHMP4B chromatin modifying protein 4A Chromatin-modifying protein 4a chromosome 14 open reading frame 123 FLJ61658 hSnf-1 HSPC134 hVps32-1 MGC142093 MGC142095 SHAX2 SNF7 homolog associated with Alix-2 Snf7 homologue associated with Alix 2 SNF7 SNF7-1 Vacuolar protein sorting-associated protein 32-1 VPS32-1 Vps32-1 VPS32A