CHMP4A Products

Antibodies
CHMP4A Antibody
CHMP4A Antibody
NBP2-49557
Species: Hu
Applications: IHC
Host: Rabbit Polyclonal
CHMP4A Antibody
CHMP4A Antibody
NBP1-79920
Species: Hu
Applications: WB
Host: Rabbit Polyclonal
CHMP4A Antibody
CHMP4A Antibody
H00029082-B01P
Species: Hu
Applications: WB
Host: Mouse Polyclonal
Lysates
CHMP4A 293T Cell Transient Ov ...
CHMP4A 293T Cell Transient Overexp...
H00029082-T01
Species: Hu
Applications: WB
Proteins
Recombinant Human CHMP4A His ...
Recombinant Human CHMP4A His Protein
NBP1-78875
Species: Hu
Applications: PAGE
CHMP4A Recombinant Protein An ...
CHMP4A Recombinant Protein Antigen
NBP2-49557PEP
Species: Hu
Applications: AC

Description

CHMP4A (charged MVB protein 4A) is one of the three isoforms of CHMP4, the human equivalent of yeast Snf7 (so CHMP4A is also referred to as hSnf7-1). It is a component of the ESCRT-III (endosomal sorting complex required for transport III) complex. The ESCRT complexes mediate membrane budding away from the cytosol and cleavage of membrane necks (membrane fission) from the cytosolic face; hence, they are key in processes such as the formation of MVBs (multivesicular bodies), enveloped virus budding, and membrane abscission in cytokinesis. Not all types of ESCRT complexes, or proteins within those complexes, are necessary for all of these functions. For instance, research into the requirements of ESCRT-III proteins in HIV-1 budding has revealed that CHMP1 and CHMP3 proteins are not essential for this process; at least one member of each of the CHMP2 and CHMP4 families are required; within these families there is some functional redundancy; within the CHMP4 family, the relative importance and abundance of the isoforms is 4B > 4A > 4C; and the absence of CHMP4A or 4B prevents the budding process from progressing to completion.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Alternate Names
  • C14orf123
  • charged multivesicular body protein 4a
  • CHMP4
  • CHMP4a
  • CHMP4B
  • chromatin modifying protein 4A
  • Chromatin-modifying protein 4a
  • chromosome 14 open reading frame 123
  • FLJ61658
  • hSnf-1
  • HSPC134
  • hVps32-1
  • MGC142093
  • MGC142095
  • SHAX2
  • SNF7 homolog associated with Alix-2
  • Snf7 homologue associated with Alix 2
  • SNF7
  • SNF7-1
  • Vacuolar protein sorting-associated protein 32-1
  • VPS32-1
  • Vps32-1
  • VPS32A