CENPH Products

Description

Centromere and kinetochore proteins play a critical role in centromere structure, kinetochore formation, and sister chromatid separation. The protein encoded by this gene colocalizes with inner kinetochore plate proteins CENP-A and CENP-C in both interphase and metaphase. It localizes outside of centromeric heterochromatin, where CENP-B is localized, and inside the kinetochore corona, where CENP-E is localized during prometaphase. It is thought that this protein can bind to itself, as well as to CENP-A, CENP-B or CENP-C. Multimers of the protein localize constitutively to the inner kinetochore plate and play an important role in the organization and function of the active centromere-kinetochore complex.

Bioinformatics

Entrez	64946 Human
Uniprot	AAH12024 Human AAH12024.1 Human NM_022909 Human NP_075060 Human NP_075060.1 Human Q9H3R5 Human
Product By Gene ID	64946
Alternate Names	CENP-H centromere protein H ICEN35 Interphase centromere complex protein 35 kinetochore protein CENP-H NNF1 PMF1

Research Areas for CENPH

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Cell Cycle and Replication