CDK2 Products

Description

The protein encoded by the Cdk2 gene is a member of the Ser/Thr protein kinase family. This protein kinase is highlysimilar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of thecyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycleG1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex includingcyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its proteinphosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have beenreported. (provided by RefSeq)

Bioinformatics

Entrez	1017 Human 12566 Mouse 362817 Rat
Uniprot	NP_001789 Human P24941 Human
Product By Gene ID	1017
Alternate Names	cdc2-related protein kinase cell devision kinase 2 Cell division protein kinase 2 cyclin-dependent kinase 2 EC 2.7.11 EC 2.7.11.22 p33 protein kinase p33(CDK2)

Diseases related to CDK2

Discover more about diseases related to CDK2.

Malignant Neoplasms
Neoplasms
Retinoblastoma
Carcinoma
Malignant Neoplasm Of Breast
Mammary Neoplasms
Cell Transformation, Neoplastic
Growth Arrest
Hyperplasia
Leukemia
Malignant Paraganglionic Neoplasm
Prostatic Neoplasms
Liver Carcinoma
Malignant Neoplasm Of Prostate
Adenocarcinoma
Malignant Tumor Of Colon
Liver Neoplasms
Malignant Squamous Cell Neoplasm
Carcinogenesis

Pathways for CDK2

View related products by pathway and learn more about each of the pathways below.

Cell Cycle
Cell Proliferation
S Phase
Cell Cycle Arrest
Cell Growth
G1 Phase
Dna Replication
Cell Death
Mitosis
Localization
Cell Division
Induction Of Apoptosis
Hyperphosphorylation
Senescence
Cell Differentiation
Proteolysis
Centrosome Duplication
Protein Phosphorylation
Angiogenesis
Rna Interference

Research Areas for CDK2

Find related products by research area and learn more about each of the different research areas below.

Breast Cancer
Cancer
Cell Cycle and Replication
Ovarian Carcinoma Cell Markers
Phospho-Specific

PTMs for CDK2

Learn more about PTMs related to CDK2.

Phosphorylation
Dephosphorylation
Cleavage
Ubiquitination
Acetylation
Methylation
Reduction
Sumoylation
Phosphorothioation
Myristoylation
Geranylgeranylation
Demethylation
Farnesylation
Carboxylation
Deacetylation
Nitrosylation
Hydroxylation
Nitration
Biotinylation

Bioinformatics Tool for CDK2

Discover related pathways, diseases and genes to CDK2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 

Related CDK2 Blog Posts

Check out the latest blog posts on CDK2.

EZH1 has more to offer than gene repression EZH1 is part of the Polycomb-group family of proteins, which are responsible for remodeling chromatin in genes and modulating epigenetic silencing during development.  Specifically, EZHI is a component of PRC2, or polycomb repressive complex-2.  PR...    Read more.

Read more CDK2 related blogs.