Cdc14A Products

Antibodies
Cdc14A Antibody
Cdc14A Antibody
NBP1-84573
Species: Hu
Applications: ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Cdc14A Antibody (2C12)
Cdc14A Antibody (2C12)
H00008556-M01
Species: Hu
Applications: WB, ELISA, ICC/IF
Host: Mouse Monoclonal
Cdc14A Antibody (1F11)
Cdc14A Antibody (1F11)
H00008556-M02
Species: Hu
Applications: WB, ELISA, ICC/IF
Host: Mouse Monoclonal
Proteins
Cdc14A Partial Recombinant Pr ...
Cdc14A Partial Recombinant Protein
H00008556-Q01
Species: Hu
Applications: WB, ELISA, PA
Cdc14A Recombinant Protein An ...
Cdc14A Recombinant Protein Antigen
NBP1-84573PEP
Species: Hu
Applications: AC
RNAi
Cdc14A RNAi
Cdc14A RNAi
H00008556-R03
Species: Hu
Cdc14A RNAi
Cdc14A RNAi
H00008556-R02
Species: Hu
Cdc14A RNAi
Cdc14A RNAi
H00008556-R01
Species: Hu

Description

Overproduction of hCdc14A leads to progressive cell death, accompanied by accumulation of pre-G1 DNA fragments and gradual elimination of cells at the G2/M transition. In 50% of the mitotic cells, multipolar mitotic spindles and misaggregated chromosomes are found. hCdc14A localizes to the centrosomes at the cell-cycle interphase stage. When the cell enters mitosis, this localization disappears suggesting that hCdc14A dissociates from the centrosomes at the G2/M transition. hCdc14A localizes to interphase centrosomes, but not to mitotic centrosomes, while hCdc14B localizes to the interphase nucleolus. Thus each isoform regulates separate cell cycle events. Cdc14A may affect cell cycle progression by its ability to dephosphorylate p53 at Ser315. This phosphatase activity is mediated by the interaction between the N-terminus of hCdc14A and the C-terminus of p53.

Bioinformatics

Entrez Human
Uniprot Human
Human
Product By Gene ID 8556
Alternate Names
  • CDC14 cell division cycle 14 homolog A
  • Cdc14A2
  • EC 3.1.3.48
  • Cdc14A1
  • EC 3.1.3.16
  • cdc14
  • hCDC14
  • CDC10 (cell division cycle 10, S. cerevisiae, homolog)
  • dual specificity protein phosphatase CDC14A
  • CDC14 cell division cycle 14 homolog A (S. cerevisiae)

Research Areas for Cdc14A

Find related products by research area and learn more about each of the different research areas below.

Cell Cycle and Replication

PTMs for Cdc14A

Learn more about PTMs related to Cdc14A.

Phosphorylation
Dephosphorylation
Ubiquitination
Demethylation
Cleavage

Bioinformatics Tool for Cdc14A

Discover related pathways, diseases and genes to Cdc14A. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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