CD83 Products

Description

CD83 is a heavily glycosylated membrane protein of the immunoglobulin (Ig) superfamily that is expressed in mature dendritic cells, Langerhans cells and interdigitating reticulum cells within lymphoid tissues. Structurally, CD83 resembles other Ig superfamily members, which have an extracellular V-type Ig-like domain, a single transmembrane domain and a 40 residue cytoplasmic tail. CD83 expression is used as a marker for mature, antigen presenting dendritic cells that are capable of generating tumor-specific T cell immunity, a phenotype with implications as an anticancer vaccine. CD83-IgG1(fc) chimera studies indicate that CD83 is a sialic acid-binding, Ig-like lectin (Siglec) adhesion molecule that is involved in cell adhesion/signaling by hosting dendritic cell interactions with monocytes and CD8+ T cells.

Bioinformatics

Entrez	9308 Human
Uniprot	Q01151
Product By Gene ID	9308
Alternate Names	B-cell activation protein BL11 BL11CD83 antigen CD83 antigen (activated B lymphocytes, immunoglobulin superfamily) CD83 molecule CD83 Cell surface protein HB15 cell-surface glycoprotein HB15 HB15hCD83

Research Areas for CD83

Find related products by research area and learn more about each of the different research areas below.

Dendritic Cell Markers