CD55/DAF Products

Description

CD55 encodes a protein involved in the regulation of the complement cascade. The encoded glycoprotein is also known as the decay-accelerating factor (DAF); binding of DAF to complement proteins accelerates their decay, disrupting the cascade and preventing damage to host cells. Antigens present on the DAF glycoprotein constitute the Cromer blood group system (CROM). Two alternatively spliced transcripts encoding different proteins have been identified. The predominant transcript encodes a membrane-bound protein expressed on cells exposed to plasma component proteins but an alternatively spliced transcript produces a soluble protein present at much lower levels. Additional, alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq]

Bioinformatics

Entrez	1604 Human
Uniprot	NM_000574 Human NP_000565 Human NP_000565.1 Human P08174 Human P08174.4 Human
Product By Gene ID	1604
Alternate Names	CD55 antigen CD55 molecule, decay accelerating factor for complement (Cromer blood group) CRdecay accelerating factor for complement (CD55, Cromer blood group system) CROMDAFcomplement decay-accelerating factor decay accelerating factor for complement TC

Research Areas for CD55/DAF

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Immunology