Species: Hu, Pm, Pm
Applications: Flow, ICC/IF, IHC, Dual ISH-IHC
Host: Mouse Monoclonal
Species: Hu
Applications: IHC, ICC/IF
Host: Mouse Monoclonal
Species: Hu, Pm, Pm
Applications: WB, Flow, ICC/IF, IHC
Host: Mouse Monoclonal
Species: Hu
Applications: Bioactivity
Description
CD45RO is a single chain transmembraneous glycoprotein which represents the low molecular weight isoform of the Leucocyte Common Antigen (LCA). It is expressed on most thymocytes, about 45% of peripheral blood T cells, virtually all T cells in skin reactive infiltrates, and the majority of T cell malignancies. It is also found on a subset of B cells and on exceptional B cell lymphomas. The CD45RA and CD45RO isoforms of the leukocyte common antigen identify functionally distinct naive and memory T cell subsets. In vitro, CD45RA+ / CD45RO - peripheral blood lymphocytes (PBL) can be converted to CD45RA- / CD45RO + phenotype upon activation in the presence of IL-2. Both CD3+ and CD3-/CD56+ lymphocyte subsets can be converted to CD45RO + lymphocytes. Expression of CD45RO was observed only in response to IL-2 and was not observed during long-term culture in IL-4, IL-6, or IL-7. This antibody recognizes an 180kDa protein, identified as isoform of leukocyte common antigen (CD45RO). This antibody reacts with mature activated T-cells, most thymocytes, and a sub-population of resting T-cells within both CD4 and CD8 subsets. Shows no reactivity with normal B or natural killer cells, but reacts with granulocytes and monocytes. Though this antibody is useful to identify T-cell lymphomas and leukemia, rare staining with B cell lymphomas reported
Bioinformatics
| Entrez |
Human
|
| Uniprot |
|
| Product By Gene ID |
5788 |
| Alternate Names |
- B220
- CD45 antigen
- CD45R
- CD45RO
- EC 3.1.3.48
- L-CA
- LY5
- protein tyrosine phosphatase, receptor type, C
- receptor-type tyrosine-protein phosphatase C
- T200 glycoprotein
- T200 leukocyte common antigen
- T200receptor type, c polypeptide
|
![Immunocytochemistry CD45RO Antibody (1066853) [Unconjugated]](http://images.novusbio.com/fullsize/antibody/mab11594_human-cd45-mab-clone-1066853-immunocytochemistry-209202413029.jpg)
![Binding Activity CD45RO [Unconjugated]](http://images.novusbio.com/fullsize/protein/10642-cd_recombinant-human-cd45ro-fc-chimera-protein-cf-binding-activity-1311202094414.jpg)
![Immunohistochemistry CD45RO Antibody (1066853) [Unconjugated]](http://images.novusbio.com/fullsize/antibody/mab11594_human-cd45-mab-clone-1066853-immunohistochemistry-2492024104623.jpg)
![SDS-PAGE CD45RO [Unconjugated]](http://images.novusbio.com/fullsize/protein/10642-cd_recombinant-human-cd45ro-fc-chimera-protein-cf-sds-page-311202014716.jpg)