Cav3.2 Products

Antibodies
Cav3.2 Antibody (S55-10)
Cav3.2 Antibody (S55-10)
NBP1-22444
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-Fr, IHC-P, IP
Host: Mouse Monoclonal
Cav3.2 Antibody
Cav3.2 Antibody
NBP2-41303
Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF, IHC, IF
Host: Rabbit Polyclonal
Cav3.2 Antibody
Cav3.2 Antibody
NBP1-88176
Species: Hu
Applications: IHC, IHC-P
Host: Rabbit Polyclonal
Proteins
Cav3.2 Recombinant Protein An ...
Cav3.2 Recombinant Protein Antigen
NBP1-88176PEP
Species: Hu
Applications: AC
RNAi
Cav3.2 RNAi
Cav3.2 RNAi
H00008912-R01
Species: Hu
Applications: RNAi, RNAi SP
Cav3.2 RNAi
Cav3.2 RNAi
H00008912-R02
Species: Hu
Applications: RNAi, RNAi SP

Description

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligandgated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inwardrectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2). Specifically, Cav3.2 is a protein which in humans is encoded by the CACNA1H gene. Studies suggest certain mutations in this gene lead to childhood absence epilepsy (3, 4). Studies also suggest that the up-regulations of Cav3.2 may participate in the progression of prostate cancer toward an androgen-independent stage (5).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Product By Gene ID 8912
Alternate Names
  • voltage-gated calcium channel alpha subunit CavT.2
  • CACNA1HB
  • voltage-gated calcium channel alpha subunit Cav3.2
  • EIG6
  • voltage-dependent T-type calcium channel subunit alpha-1H
  • ECA6
  • voltage dependent t-type calcium channel alpha-1H subunit
  • Voltage-gated calcium channel subunit alpha Cav3.2
  • low-voltage-activated calcium channel alpha13.2 subunit
  • Low-voltage-activated calcium channel alpha1 3.2 subunit
  • calcium channel, voltage-dependent, T type, alpha 1Hb subunit
  • Cav3.2
  • FLJ90484
  • calcium channel, voltage-dependent, T type, alpha 1H subunit

PTMs for Cav3.2

Learn more about PTMs related to Cav3.2.

Phosphorylation
Biotinylation
Methylation
Oxidation
Ribosylation

Bioinformatics Tool for Cav3.2

Discover related pathways, diseases and genes to Cav3.2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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