Cav3.2 Products

Description

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligandgated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inwardrectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2). Specifically, Cav3.2 is a protein which in humans is encoded by the CACNA1H gene. Studies suggest certain mutations in this gene lead to childhood absence epilepsy (3, 4). Studies also suggest that the up-regulations of Cav3.2 may participate in the progression of prostate cancer toward an androgen-independent stage (5).

Bioinformatics

Entrez	114862 Rat 58226 Mouse 8912 Human
Uniprot	O95180 Human
Product By Gene ID	8912
Alternate Names	CACNA1HB calcium channel, voltage-dependent, T type, alpha 1H subunit calcium channel, voltage-dependent, T type, alpha 1Hb subunit Cav3.2 ECA6 EIG6 FLJ90484 Low-voltage-activated calcium channel alpha1 3.2 subunit low-voltage-activated calcium channel alpha13.2 subunit voltage dependent t-type calcium channel alpha-1H subunit voltage-dependent T-type calcium channel subunit alpha-1H voltage-gated calcium channel alpha subunit Cav3.2 voltage-gated calcium channel alpha subunit CavT.2 Voltage-gated calcium channel subunit alpha Cav3.2