Calreticulin Products

Antibodies
Calreticulin Antibody
Calreticulin Antibody
NB600-103
Species: Hu, Mu
Applications: WB, Simple Western, ICC/IF, IHC, KD, KO
Host: Rabbit Polyclonal
ELISA Kits
Mouse Calreticulin ELISA Kit ...
Mouse Calreticulin ELISA Kit (Colo...
NBP3-06820
Species: Mu
Applications: ELISA
Human Calreticulin ELISA Kit ...
Human Calreticulin ELISA Kit (Colo...
NBP3-06819
Species: Hu
Applications: ELISA
Rat Calreticulin ELISA Kit (C ...
Rat Calreticulin ELISA Kit (Colori...
NBP3-06821
Species: Rt
Applications: ELISA
Lysates
Calreticulin Overexpression L ...
Calreticulin Overexpression Lysate
NBL1-08655
Species: Hu
Applications: WB
Proteins
Recombinant Human Calreticuli ...
Recombinant Human Calreticulin His...
NBP1-44499
Species: Hu
Applications: PAGE

Description

Calreticulin, also called CALR, is an endoplasmic reticulum (ER) protein that functions as a calcium (Ca2+) buffering molecular chaperone (1-3). Together with calnexin and ERp57, calreticulin has a critical role in protein folding and quality control of newly synthesized glycoproteins (1-3). Calreticulin has many diverse functions beyond Ca2+ binding, including cell adhesion, lectin binding, apoptosis, nuclear transport, antigen presentation, and immune response (1-3). Specifically, calreticulin is part of the peptide-loading complex that resides on the ER membrane and is responsible for antigen loading onto MHC class I molecules (1-3). Calreticulin protein has a theoretical molecular weight of 46 kDa and is 417 amino acids (aa) in length (1-3). The protein has three main domains: the N-terminal lectin-like domain, the proline-rich P-domain, and the acidic C-domain which is followed by an ER-retention KDEL signal sequence (1-3).

Given its role in multiple biological processes, it makes sense that calreticulin is implicated in both healthy and disease states. Studies have found that calreticulin mutations were present in patients with myeloproliferative neoplasms (MFN) and essential thrombocythaemia (ET) (4). Calreticulin expression is typically upregulated in most cancer lines, however it is downregulated in some tissues including cervical carcinomas, prostate cancer, and human colon adenocarcinoma (3). High expression of calreticulin on cancer cells is related to tumor cell phagocytosis and is often correlated with, and counteracted by, elevated CD47 expression to prevent cancer cell phagocytosis (3). Calreticulin mutations can serve as a major diagnostic biomarker for MFN and ET and additionally the calreticulin gene may be a potential target for cancer therapeutics (3,4).

References

1. Michalak, M., Groenendyk, J., Szabo, E., Gold, L. I., & Opas, M. (2009). Calreticulin, a multi-process calcium-buffering chaperone of the endoplasmic reticulum. The Biochemical Journal. https://doi.org/10.1042/BJ20081847

2. Fucikova, J., Spisek, R., Kroemer, G., & Galluzzi, L. (2021). Calreticulin and cancer. Cell Research. https://doi.org/10.1038/s41422-020-0383-9

3. Sun, J., Mu, H., Dai, K., & Yi, L. (2017). Calreticulin: a potential anti-cancer therapeutic target. Die Pharmazie. https://doi.org/10.1691/ph.2017.7031

4. Prins, D., Gonzalez Arias, C., Klampfl, T., Grinfeld, J., & Green, A. R. (2020). Mutant Calreticulin in the Myeloproliferative Neoplasms. HemaSphere. https://doi.org/10.1097/HS9.0000000000000333

Bioinformatics

Entrez Mouse
Mouse
Rat
Human
Uniprot Human
Human
Human
Human
Human
Mouse
Human
Product By Gene ID 811
Alternate Names
  • autoantigen Ro
  • CALR
  • Calregulin
  • calregulin
  • calreticulin
  • cC1qR
  • CRP55
  • CRT
  • Endoplasmic reticulum resident protein 60
  • epididymis secretory sperm binding protein Li 99n
  • ERp60
  • FLJ26680
  • grp60
  • HACBP
  • HEL-S-99n
  • RO
  • Sicca syndrome antigen A (autoantigen Ro; calreticulin)
  • SSA

Research Areas for Calreticulin

Find related products by research area and learn more about each of the different research areas below.

Autophagy
Cancer
Cellular Markers
ER Markers
Membrane Trafficking and Chaperones
Neuroscience
Neurotransmission
Signal Transduction

PTMs for Calreticulin

Learn more about PTMs related to Calreticulin.

Phosphorylation
Cleavage
Glycosylation
Methylation

Related Calreticulin Blog Posts

Check out the latest blog posts on Calreticulin.
Calreticulin: a Multiprocess Calcium Buffering Chaperone
Calreticulin is a Calcium binding chaperone that has multiple functions both inside and outside the endoplasmic reticulum. Calreticulin is involved in the quality control of newly synthesized proteins and glycoproteins, interacting with various other ...    Read more.
Calnexin - an ER chaperone that folds the cell's glycoproteins
Calnexin is an abundant 90kDa chaperone protein that resides in the membrane of the endoplasmic reticulum. Calnexin and the related calreticulin protein function together to ensure the proper folding of glycoproteins. By binding to partially folded...    Read more.
Calreticulin - ER chaperone involved in calcium homeostasis and protein quality control
Calreticulin is a calcium-dependent ER chaperone, involved in protein folding, maturation, and cellular localization. Calreticulin is a highly conserved 48 kDa protein encoded by the CALR gene. Calreticulin and its homolog calnexin regulate the fo...    Read more.
Read more Calreticulin related blogs.