Hu, Mu, Rt, Bv, Ha, PmApplications:
WB, Simple Western, DB, EM, Flow, ICC/IF, IHC, IHC-P, IP, PA, B/N, KDHost:
WB, Simple Western, ICC/IF, IHC, IHC-Fr, IHC-P, KDHost:
WB, ELISA, Flow, Flow-IC, ICC/IF, IHC, IHC-PHost:
Calreticulin (CALR) is a multifunctional, highly conserved Ca2+ -binding protein that is localized to the endoplasmic reticulum (ER). Calreticulin acts as a molecular chaperone and is involved in protein folding events in the ER. CALR has also been shown to interact with the cytoskeleton and to be involved in the regulation of gene expression. Calreticulin may play a role in cellular proliferation including its apparent activity in the proliferation of certain viruses within mammalian host cells. Recently, it has been shown that calreticulin is induced in response to various types of cell stress including amino acid deprivation.
Close interconnections among protein synthesis, gene expression and calcium signaling have been observed by many researchers in recent years. Calreticulin is thought to be a central protein in the coordination of these functions by the cell. Therefore, Calreticulin antibodies will serve as useful tools for any of these interconnected research areas.