CAD Products

Antibodies
CAD Antibody
CAD Antibody
NB100-61614
Species: Hu, Mu, Canine, Primate, Porcine, Monkey
Applications: WB, ICC/IF, IHC, IHC-P, IP
Host: Rabbit Polyclonal
CAD Antibody
CAD Antibody
NBP1-77009
Species: Mu, Rt
Applications: WB, ELISA, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
CAD Antibody
CAD Antibody
NB100-61613
Species: Hu, Mu, Canine, Guinea Pig, Primate, Porcine, Rabbit, Rat, Bat, Chinese Hamster
Applications: WB, ICC/IF, IHC, IHC-P, IP (-)
Host: Rabbit Polyclonal
Proteins
CAD Peptide
CAD Peptide
NBP1-77001PEP
Species: Mu
Applications: AC
CAD Peptide
CAD Peptide
NBP1-77009PEP
Species: Mu
Applications: AC
RNAi
CAD RNAi
CAD RNAi
H00000790-R01
Species: Hu

Description

Carbamoyl phosphate synthetase-aspartate carbamoyltransferase-dihydroorotase (CAD) is a multifunctional protein that initiates and regulates mammalian de novo pyrimidine biosynthesis (1). This trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis is the rate-limiting step in the de novo pyrimidine synthetic pathway (2). Although most of the CAD protein in the cell is cytosolic, phosphorylation at threonine 456 localizes the protein to the nucleus (3). While MAPK and EGF phosphorylate CAD at threonine 456, MAPK and c-myc have been found to induce over-expression of CAD (4-5).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Product By Gene ID 790
Alternate Names
  • multifunctional protein CAD
  • EC 6.3.5.5
  • CAD trifunctional protein
  • EC 6.3.5
  • CAD protein
  • EC 3.5.2.3
  • EC 2.1.3.2
  • carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, anddihydroorotase

Research Areas for CAD

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Cell Biology
Cell Cycle and Replication
Lipid and Metabolism

Bioinformatics Tool for CAD

Discover related pathways, diseases and genes to CAD. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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