Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu, Mu
Applications: WB, IHC, IP
Host: Rabbit Polyclonal
Species: Hu, Mu
Applications: WB, ICC/IF, IHC
Host: Rabbit Monoclonal
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
Carbamoyl phosphate synthetase-aspartate carbamoyltransferase-dihydroorotase (CAD) is a multifunctional protein that initiates and regulates mammalian de novo pyrimidine biosynthesis (1). This trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis is the rate-limiting step in the de novo pyrimidine synthetic pathway (2). Although most of the CAD protein in the cell is cytosolic, phosphorylation at threonine 456 localizes the protein to the nucleus (3). While MAPK and EGF phosphorylate CAD at threonine 456, MAPK and c-myc have been found to induce over-expression of CAD (4-5).
Bioinformatics
| Entrez |
Rat
Mouse
Human
|
| Uniprot |
Human
Human
|
| Product By Gene ID |
790 |
| Alternate Names |
- CAD protein
- CAD trifunctional protein
- carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, anddihydroorotase
- EC 2.1.3.2
- EC 3.5.2.3
- EC 6.3.5
- EC 6.3.5.5
- multifunctional protein CAD
|
