CAD Products

Description

Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation ofchromosomal DNA by activated DNase. A mouse DNase that causes DNA fragmentation was identified recently and designated CAD, which stands for caspase activated deoxyribonuclease (1,2). The human homologue of mouse CAD was more recently identified by two groups independently and termed CPAN and DFF40 (3,4). Human DFF45 and its mouse homologue ICAD are the inhibitors of CPAN/DFF40 and CAD, respectively (1, 2, 5). Upon cleavage of DFF45/ICAD by activated caspase, DFF40/CAD is released and activated and eventually causes the degradation of DNA in the nuclei (1-4). Activation of CAD/DFF40, which causes DNA degradation, is the hallmark of apoptotic cell death.

Bioinformatics

Entrez	69719 Mouse
Product By Gene ID	790
Alternate Names	CAD protein CAD trifunctional protein carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, anddihydroorotase EC 2.1.3.2 EC 3.5.2.3 EC 6.3.5 EC 6.3.5.5 multifunctional protein CAD

Research Areas for CAD

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Cell Biology
Cell Cycle and Replication