CACNA2D2 Products

Description

The CACNA2D2 gene encodes a voltage-dependent calcium channel subunit alpha-2/delta-2 protein that exists in 5 isoforms: isoform 1: 1,150 amino acids long, 129 kDA; isoform 2: 1,143 amino acids long, 129 kDA; isoform 3: 1,145 amino acids long, 129 kDA; isoform 4: 1,076 amino acids long, 122 kDA; and isoform 5: 1,152 amino acids long, 130 kDA. These proteins are critical in calcium current density and in activation and inactivation kinetics of the calcium channel. Additionally, these proteins function as regulatory subunits for P/Q-type calcium channel, N-type, and L-type, as well as T-type. Overexpression of this gene triggers apoptosis. The CACNA2D2 gene participates in transcription of the CREB pathway, the caspase cascade, Fc-GammaR pathway, BMP and PDGF pathways, regulation of insulin secretion, and transmission across chemical synapses. It is known to interact with genes DLG4, CACNA1C, CACNA1D, CACNA1F, and YWHAB. The CACNA2D2 gene is associated with ataxia, seizures, lung cancer, and neuronitis.

Bioinformatics

Entrez	300992 Rat 56808 Mouse 9254 Human
Uniprot	NP_006021 Human P54289 Human
Product By Gene ID	9254
Alternate Names	alpha 2 delta calcium channel subunit CACNA2D calcium channel, voltage-dependent, alpha 2/delta subunit 2 gene 26 KIAA0558Voltage-gated calcium channel subunit alpha-2/delta-2 LUAC11.1 voltage-dependent calcium channel subunit alpha-2/delta-2