CACNA1S Products

Antibodies
CACNA1S Antibody
CACNA1S Antibody
NBP2-33541
Species: Hu
Applications: IHC, IHC-P
Host: Rabbit Polyclonal
CACNA1S Antibody
CACNA1S Antibody
NBP1-31659
Species: Hu
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
Proteins
CACNA1S Partial Recombinant P ...
CACNA1S Partial Recombinant Protein
H00000779-Q01
Species: Hu
Applications: WB, ELISA, PA
CACNA1S Recombinant Protein A ...
CACNA1S Recombinant Protein Antigen
NBP2-33541PEP
Species: Hu
Applications: AC
CACNA1S Recombinant Protein A ...
CACNA1S Recombinant Protein Antigen
NBP2-33799PEP
Species: Hu
Applications: AC
RNAi
CACNA1S RNAi
CACNA1S RNAi
H00000779-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

Voltage-sensitive calcium channels mediate the entry of calcium into many types of excitable cells and thus play a key role in neurotransmitter release and excitation-contraction (E-C) coupling. The 1,4-dihydropyridines (DHPs) are synthetic organic compounds which can be used to identify the L-type calcium channels that are found in all types of vertebrate muscle, neuronal and neuroendocrine cells. The DHP receptor is part of the L-type calcium channel complex and is thought to be the voltage sensor in E-C coupling.The purified DHP receptor isolated from triads is composed of at least four subunits. The alpha-1 subunit contains the binding site for the DHPs and shows high sequence homology to the voltage gated sodium channel. The alpha-2 subunit is a large glycoprotein associated with the DHP receptor which was first described in skeletal muscle and is also found in high concentrations in other excitable tissues such as cardiac muscle and brain and in low concentrations in most other tissues studied. The other two subunits that co-purify with the DHP receptor are termed beta and gamma.

Bioinformatics

Entrez Human
Rat
Uniprot Human
Product By Gene ID 779
Alternate Names
  • TTPP1
  • CACN1
  • HOKPP1
  • CACH1
  • CCHL1A3
  • voltage-dependent L-type calcium channel subunit alpha-1S
  • Voltage-gated calcium channel subunit alpha Cav1.1
  • dihydropyridine-sensitive L-type calcium channel alpha-1 subunit
  • Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle
  • dihydropyridine receptor
  • hypoPP
  • hypokalemic periodic paralysis)
  • calcium channel, L type, alpha 1 polypeptide, isoform 3 (skeletal muscle
  • Cav1.1
  • CACNL1A3MHS5
  • HOKPP
  • calcium channel, voltage-dependent, L type, alpha 1S subunit

Research Areas for CACNA1S

Find related products by research area and learn more about each of the different research areas below.

Neuroscience
Signal Transduction

Bioinformatics Tool for CACNA1S

Discover related pathways, diseases and genes to CACNA1S. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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