c-Myb Products

Description

The c-Myb proto-oncogene is a 75 kDa protein involved in growth regulation and differentiation in many different cell types but it is predominantly expressed in immature hemopoietic cells where it plays an important role in cell proliferation. c-Myb activity is directly regulated by cyclin D1 and CDKs and it is believed that c-Myb activity is regulated during the cell cycle in hematopoietic cells (2). Disrupting c-myb function might, therefore, prove an effective therapeutic strategy for controlling leukemic cell growth (3). c-Myb binds to promoter sequences of genes such as c-Myc or Bcl-2 that are expressed in cutaneous T-cell lymphoma.

Bioinformatics

Entrez	17863 Mouse 293405 Rat 4602 Human
Uniprot	AAH64955 Human CAE55174 Human EAW47967 Human NM_005375 Human NP_001123645.1 Human NP_005366.2 Human P06876 Mouse P10242 Human
Product By Gene ID	4602
Alternate Names	c-myb protein (140 AA) Cmyb c-myb c-myb_CDS c-myb10A_CDS c-myb13A_CDS c-myb14A_CDS c-myb8B_CDS efg Proto-oncogene c-Myb transcriptional activator Myb v-myb avian myeloblastosis viral oncogene homolog v-myb myeloblastosis viral oncogene homolog (avian)

Research Areas for c-Myb

Find related products by research area and learn more about each of the different research areas below.

Cancer
Phospho-Specific