BTK Products

Antibodies
Lysates
BTK Overexpression Lysate (Na ...
BTK Overexpression Lysate (Native)
NBP2-09059
Applications: WB
Proteins
BTK [p Tyr223] Peptide
BTK [p Tyr223] Peptide
NBP1-78295PEP
Species: Hu
BTK Partial Recombinant Prote ...
BTK Partial Recombinant Protein
H00000695-Q01
Species: Hu
Applications: WB, ELISA, PA
BTK Recombinant Protein
BTK Recombinant Protein
H00000695-P01
Species: Hu
Applications: WB, ELISA, PA
RNAi
BTK RNAi
BTK RNAi
H00000695-R03
Species: Hu

Description

Brutons tyrosine kinase (BTK) is a member of the BTK/Tec family of cytoplasmic tyrosine kinases. All members of the BTK/Tec family contain SH3 and SH2 domains and, with the exception of Txk and Dsrc28C, also contain a pleckstrin homology (PH) and a Tec homology (TH) domain in their amino termini. BTK plays an important role in B cell development. Activation of B cells by various ligands is accompanied by BTK membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. The membrane located BTK is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinase, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Product By Gene ID 695
Alternate Names
  • EC 2.7.10
  • EC 2.7.10.2
  • Bruton tyrosine kinase
  • B-cell progenitor kinase
  • tyrosine-protein kinase BTK
  • BPK
  • dominant-negative kinase-deficient Brutons tyrosine kinase
  • Agammaglobulinaemia tyrosine kinase
  • PSCTK1
  • AGMX1MGC126262
  • XLAMGC126261
  • ATKIMD1
  • AT
  • Bruton agammaglobulinemia tyrosine kinase

Research Areas for BTK

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Immunology
Innate Immunity
Phospho-Specific

Bioinformatics Tool for BTK

Discover related pathways, diseases and genes to BTK. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related BTK Blog Posts

Check out the latest blog posts on BTK.
CD79b - A Signal Transduction Component of the B-cell Receptor
The B-cell antigen receptor (BCR) is a complex multimeric aggregate that includes the following key noncovalently-bound components: antigen-specific surface immunoglobulin (Ig), CD79a (Ig-alpha), and CD79b (Ig-beta). BCR signaling is a pivotal pathway...    Read more.
Read more BTK related blogs.