BTK Products

BTK Antibody
BTK Antibody
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
BTK Overexpression Lysate
BTK Overexpression Lysate
Species: Hu
Applications: WB
BTK [p Tyr223] Blocking Pepti ...
BTK [p Tyr223] Blocking Peptide
Species: Hu
Recombinant Human BTK Protein ...
Recombinant Human BTK Protein
Species: Hu
Applications: WB, ELISA, PA, AP
Recombinant Human BTK Protein ...
Recombinant Human BTK Protein
Species: Hu
Applications: WB, ELISA, PA, AP


Brutons tyrosine kinase (BTK) is a member of the BTK/Tec family of cytoplasmic tyrosine kinases. All members of the BTK/Tec family contain SH3 and SH2 domains and, with the exception of Txk and Dsrc28C, also contain a pleckstrin homology (PH) and a Tec homology (TH) domain in their amino termini. BTK plays an important role in B cell development. Activation of B cells by various ligands is accompanied by BTK membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. The membrane located BTK is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinase, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation.


Entrez Human
Uniprot Human
Product By Gene ID 695
Alternate Names
  • EC 2.7.10
  • EC
  • Bruton tyrosine kinase
  • B-cell progenitor kinase
  • tyrosine-protein kinase BTK
  • BPK
  • dominant-negative kinase-deficient Brutons tyrosine kinase
  • Agammaglobulinaemia tyrosine kinase
  • PSCTK1
  • AGMX1MGC126262
  • XLAMGC126261
  • AT
  • Bruton agammaglobulinemia tyrosine kinase

Research Areas for BTK

Find related products by research area and learn more about each of the different research areas below.

Innate Immunity

Bioinformatics Tool for BTK

Discover related pathways, diseases and genes to BTK. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Vizit™, under license from BioVista Inc.

Related BTK Blog Posts

Check out the latest blog posts on BTK.
Repurposing FDA-approved drugs to combat the rise of antibiotic resistance
By Beth Melson, MSAntibiotic resistance is a global threat to public health. Widespread, inappropriate use of antibiotics, such as to treat viral infections or promote growth in livestock, has led to increased incid...    Read more.
CD79b - A Signal Transduction Component of the B-cell Receptor
The B-cell antigen receptor (BCR) is a complex multimeric aggregate that includes the following key noncovalently-bound components: antigen-specific surface immunoglobulin (Ig), CD79a (Ig-alpha), and CD79b (Ig-beta). BCR signaling is a pivotal pathway...    Read more.
Read more BTK related blogs.