BTK Products

Description

Brutons tyrosine kinase (BTK) is a member of the BTK/Tec family of cytoplasmic tyrosine kinases. All members of the BTK/Tec family contain SH3 and SH2 domains and, with the exception of Txk and Dsrc28C, also contain a pleckstrin homology (PH) and a Tec homology (TH) domain in their amino termini. BTK plays an important role in B cell development. Activation of B cells by various ligands is accompanied by BTK membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. The membrane located BTK is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinase, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation.

Bioinformatics

Entrez	12229 Mouse 367901 Rat 695 Human
Uniprot	NM_000061 Human NP_000052 Human Q06187 Human
Product By Gene ID	695
Alternate Names	Agammaglobulinaemia tyrosine kinase AGMX1MGC126262 AT ATKIMD1 B-cell progenitor kinase BPK Bruton agammaglobulinemia tyrosine kinase Bruton tyrosine kinase dominant-negative kinase-deficient Brutons tyrosine kinase EC 2.7.10 EC 2.7.10.2 PSCTK1 tyrosine-protein kinase BTK XLAMGC126261

Research Areas for BTK

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Immunology
Innate Immunity
Phospho-Specific

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