Borealin Products

Description

Borealin (CDCA8) is a component of the chromosomal passenger complex (CPC), which is required for stability of the bipolar mitotic spindle and acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA.

Borealin has been shown to interact with Aurora B and survivin (BIRC5). Knockdown of Borealin by small interfering RNA resulted in severe chromosome misalignment at metaphase and accumulation of multiple interphase nuclei. Borealin is also related to the proliferation of human embryonic stem (hES) cells and is highly expressed in mouse undifferentiated ES cells.
Borealin antibodies are useful tools for stem cell studies and cell division research.

Bioinformatics

Entrez	55143 Human 52276 Mouse 500545 Rat
Uniprot	NP_060571 Human NP_060571.1 Human AAH16944 Human AAH16944.1 Human Q53HL2 Human
Product By Gene ID	55143
Alternate Names	PESCRG3 hDasra-B Dasra-B Pluripotent embryonic stem cell-related gene 3 protein dasra-B Cell division cycle-associated protein 8 Dasra B MESRGP borealin FLJ12042 DasraB FLJ10468 BOR BOREALIN cell division cycle associated 8

Diseases related to Borealin

Discover more about diseases related to Borealin.

Malignant Neoplasms
Neoplasms
Endometrial Polyp
Aneuploidy
Carcinoma
Malignant Neoplasm Of Ovary
Ovarian Neoplasm
Cell Transformation, Neoplastic
Polyploidy
Malignant Neoplasm Of Stomach
Cholangiocarcinoma
Stomach Neoplasms
Fracture Of First Cervical Vertebra
Stenosis
Tumor Progression
Uterine Cervical Neoplasm
Malignant Tumor Of Cervix
Malignant Neoplasm Of Lung
Carcinogenesis
Neoplasms, Glandular And Epithelial

Pathways for Borealin

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Mitosis
Cytokinesis
Cell Division
Localization
Cell Cycle
Chromosome Segregation
Spindle Assembly
Anaphase
Spindle Assembly Checkpoint
Transport
Nuclear Transport
Sister Chromatid Cohesion
Meiosis
Cell Proliferation
Metaphase
Abscission
Spindle Checkpoint
S Phase
Cell Adhesion
Immune Response

Research Areas for Borealin

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Cell Biology
Cell Cycle and Replication
Chromatin Research
Core ESC-Like Genes
Mitotic Regulators
Stem Cell Markers
Zinc Finger

PTMs for Borealin

Learn more about PTMs related to Borealin.

Phosphorylation
Dephosphorylation
Cleavage
Methylation

Bioinformatics Tool for Borealin

Discover related pathways, diseases and genes to Borealin. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.