Borealin Products

Antibodies
Borealin Antibody
Borealin Antibody
NBP1-89951
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Borealin Antibody (4G3)
Borealin Antibody (4G3)
NBP2-46199
Species: Hu
Applications: WB, IHC
Host: Mouse monoclonal
Antibody Pairs
Borealin Antibody Pair
Borealin Antibody Pair
H00055143-PW1
Species: Hu
Applications: WB, IP
Lysates
Borealin Overexpression Lysat ...
Borealin Overexpression Lysate (De...
H00055143-T01
Species: Hu
Applications: WB
Borealin Overexpression Lysat ...
Borealin Overexpression Lysate (De...
H00055143-T02
Species: Hu
Applications: WB
Proteins
Borealin Peptide
Borealin Peptide
NBP1-22832PEP
Species: Hu
Borealin Recombinant Protein ...
Borealin Recombinant Protein Antigen
NBP1-89949PEP
Species: Hu
Applications: AC
Borealin Recombinant Protein ...
Borealin Recombinant Protein Antigen
NBP1-89951PEP
Species: Hu
Applications: AC
RNAi
Borealin RNAi
Borealin RNAi
H00055143-R01
Species: Hu

Description

Borealin (CDCA8) is a component of the chromosomal passenger complex (CPC), which is required for stability of the bipolar mitotic spindle and acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA.

Borealin has been shown to interact with Aurora B and survivin (BIRC5). Knockdown of Borealin by small interfering RNA resulted in severe chromosome misalignment at metaphase and accumulation of multiple interphase nuclei. Borealin is also related to the proliferation of human embryonic stem (hES) cells and is highly expressed in mouse undifferentiated ES cells.
Borealin antibodies are useful tools for stem cell studies and cell division research.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 55143
Alternate Names
  • PESCRG3
  • hDasra-B
  • Dasra-B
  • Pluripotent embryonic stem cell-related gene 3 protein
  • dasra-B
  • Cell division cycle-associated protein 8
  • Dasra B
  • MESRGP
  • borealin
  • FLJ12042
  • DasraB
  • FLJ10468
  • BOR
  • BOREALIN
  • cell division cycle associated 8

Research Areas for Borealin

Find related products by research area and learn more about each of the different research areas below.

Cell Biology
Cell Cycle and Replication
Chromatin Research
Core ESC-Like Genes
Mitotic Regulators
Stem Cell Markers
Zinc Finger

PTMs for Borealin

Learn more about PTMs related to Borealin.

Phosphorylation
Dephosphorylation
Cleavage
Methylation

Bioinformatics Tool for Borealin

Discover related pathways, diseases and genes to Borealin. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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