Borealin Products

Description

Borealin (CDCA8) is a component of the chromosomal passenger complex (CPC), which is required for stability of the bipolar mitotic spindle and acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA.

Borealin has been shown to interact with Aurora B and survivin (BIRC5). Knockdown of Borealin by small interfering RNA resulted in severe chromosome misalignment at metaphase and accumulation of multiple interphase nuclei. Borealin is also related to the proliferation of human embryonic stem (hES) cells and is highly expressed in mouse undifferentiated ES cells.
Borealin antibodies are useful tools for stem cell studies and cell division research.

Bioinformatics

Entrez	500545 Rat 52276 Mouse 55143 Human
Uniprot	AAH16944 Human AAH16944.1 Human NP_060571 Human NP_060571.1 Human Q53HL2 Human
Product By Gene ID	55143
Alternate Names	BOR BOREALIN borealin cell division cycle associated 8 Cell division cycle-associated protein 8 Dasra B DasraB dasra-B Dasra-B FLJ10468 FLJ12042 hDasra-B MESRGP PESCRG3 Pluripotent embryonic stem cell-related gene 3 protein

Research Areas for Borealin

Find related products by research area and learn more about each of the different research areas below.

Cell Biology
Cell Cycle and Replication
Chromatin Research
Core ESC-Like Genes
Mitotic Regulators
Stem Cell Markers
Zinc Finger