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MAB0041, open histogram), followed by Allophycocyanin-conjugated Anti-Mouse IgG F(ab')2Secondary Antibody (Catalog # F0101B)." class="big_lightbox" target="_blank">
SC030B) were stained with Mouse Anti-Human BMPR-IB/ALK-6 Monoclonal Antibody (Catalog # MAB5051, filled histogram) or isotype control antibody (Catalog # MAB0041, open histogram) followed by anti-Mouse IgG PE-conjugated secondary antibosy (Catalog # F0101B). View our protocol for Staining Membrane-associated Proteins." class="big_lightbox" target="_blank">
NL007) and counterstained with DAPI (blue). Specific staining was localized to the cytoplasm and cell surface. View our protocol for Fluorescent ICC Staining of Cells on Coverslips." class="big_lightbox" target="_blank">
BMPR1B encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension.
![Flow Cytometry BMPR-IB/ALK-6 Antibody (477914) [Unconjugated]](http://images.novusbio.com/images/antibody/BMPR-IB_MAB5051_Flow_Cytometry_8516.jpg)
![Flow Cytometry BMPR-IB/ALK-6 Antibody (477914) [Unconjugated]](http://images.novusbio.com/images/antibody/BMPRIB_MAB5051_Flow_Cytometry_22823.jpg)
![Immunocytochemistry BMPR-IB/ALK-6 Antibody (477914) [Unconjugated]](http://images.novusbio.com/images/antibody/BMPRIB_MAB5051_Immunocytochemistry__Immunofluorescence_17784.jpg)
