Species: Hu, Mu, Rt, Bv, Po, Ca, Ch, RM, Sh
Applications: WB, IHC, IHC-Fr, IHC-P
Host: Rabbit Polyclonal
BMPR1B encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension.
|Product By Gene ID
- EC 2.7.11
- CDw293 antigen
- EC 220.127.116.11
- serine/threonine receptor kinase
- BMP type-1B receptor
- bone morphogenetic protein receptor type-1B
- activin receptor-like kinase 6
- bone morphogenetic protein receptor, type IB
Bioinformatics Tool for BMPR-IB/ALK-6
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