BLAME/SLAMF8 Products

Description

B-lymphocyte activator macrophage expressed (BLAME), also known as SLAMF8, is a type I transmembrane protein that belongs to the CD2 subset of immunoglobulin superfamily cell receptors. The SLAM family is comprised of nine surface receptors, expressed mainly on hematopoietic cells, and they have been shown to function as adhesion molecules and modulators of immune responses (1). BLAME, along with SLAMF2 and SLAMF9, are considered atypical SLAM family members due to the low homology in their cytoplasmic domains compared to the rest of the SLAM family (2). Mature cynomologus BLAME consists of an extracellular domain (ECD) with an IgV and an IgC2 domain, a transmembrane segment, and a short cytoplasmic domain. Within the ECD, cynomologus BLAME shares 96% amino acid sequence identity with human BLAME. BLAME is expressed by various myeloid cells, such as neutrophils, macrophages, and dendritic cells (3). BLAME suppresses macrophage function but enhances the growth of neoplastic mast cells via SHP-2 (4). BLAME negatively regulates the activity of PKC-δ, which phosphorylates the p40phox subunit of the NOX2 complex (5). BLAME is abundantly expressed in T cells in pediatric cancers and Epstein-Barr virus-positive gastric cancers and is a potential immunotherapy target for several diseases (6-8). Higher SLAMF8 expression may predict better anti-PD1 immunotherapy efficacy in GI cancer (9).

Bioinformatics

Uniprot	XP_005541356.1
Product By Gene ID	56833
Alternate Names	B Lymphocyte Activator Macrophage Expressed BCM-Like Membrane Protein BLAME B-Lymphocyte Activator Macrophage Expressed CD353 Antigen CD353 SBBI42 SLAM Family Member 8 SLAMF8