BIN1 Products

Description

BIN1 encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynanim, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.

Bioinformatics

Entrez	117028 Rat 274 Human 30948 Mouse
Uniprot	AAH04101 Human NP_004296 Human NP_004296.1 Human NP_647593 Human NP_647594 Human NP_647598 Human NP_647598.1 Human NP_647600 Human O00499 Human
Product By Gene ID	274
Alternate Names	AMPH2 Amphiphysin II Amphiphysin-like protein AMPHLDKFZp547F068 box dependant MYC interacting protein 1 bridging integrator 1Box-dependent myc-interacting protein 1 MGC10367 myc box-dependent-interacting protein 1 SH3P9

Research Areas for BIN1

Find related products by research area and learn more about each of the different research areas below.

Cell Cycle and Replication
Tumor Suppressors