BID Products

Description

Bid (BCL-2 Interacting Domain) protein belongs to an important class of regulators of apoptosis. It is localized in the cytosolic fraction of cells as an inactive precursor. Its active form is generated upon proteolytic cleavage by caspase 8 in the Fas signaling pathway. Cleaved Bid translocates to mitochondria and induces cytochrome c release and mitochondrial damage. The cytochrome c releasing activity of Bid is antagonized by Bcl2.

Bioinformatics

Entrez	637 Human
Uniprot	NP_932070.1 Human
Product By Gene ID	637
Alternate Names	apoptic death agonist BH3 interacting domain death agonist BH3-interacting domain death agonist BID isoform ES(1b) BID isoform L(2) BID isoform Si6 BID desmocollin type 4 FP497 Human BID coding sequence MGC15319 MGC42355 p22 BID tbid

Research Areas for BID

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Tumor Suppressors

Related BID Blog Posts

Check out the latest blog posts on BID.

Apoptosis and Necroptosis Part I: Important factors to identify both types of programmed cell death Different types of cell death have classically been identified by discrete morphological changes. The hallmarks of apoptosis include cell shrinkage, nuclear fragmentation and membrane blebbing whereas necroptosis is characterized by cell swelling ...    Read more.

The use of apoptosis antibodies and controls in cell death research Apoptosis is a method of programmed cell death that is notably characterized by a morphological change in cellular nuclei and membrane appearance.  Not to be confused with necrosis, apoptosis is a pathway that is induced by a variety of factors tha...    Read more.

The role of p53 in UV radiation DNA damage and subsequent tumorogenesis p53, the protein product of the tp53 gene, is one of the most widely studied tumor suppressor proteins in cancer research.  p53 is unique in that it demonstrates both tumor suppressive and tumor progressive properties depending on whether it is fu...    Read more.

active/cleaved Caspase 2 - Inducing apoptosis in response to cellular stress Caspase-2 is a highly conserved member of the caspase family involved in the initiation and execution of apoptosis. While its function is still poorly understood, caspase-2 is thought to be important for apoptosis in response to DNA damage, bacteri...    Read more.

Bcl-2 - an antiapoptotic protein with an important role in cancer cell survival B-cell lymphoma 2 (Bcl-2) protein is an oncogene that normally acts as an apoptotic inhibitor and localizes to the mitochondrial membrane where it prevents the release of cytochrome c. The Bcl-2 protein family consists of over 20 proteins each co...    Read more.

Read more BID related blogs.