BID Products

Antibodies
BID Antibody
BID Antibody
NB100-56106
Species: Hu, Mu, Rt, Ca, Ge
Applications: WB, IHC, IHC-Fr, IHC-P, IP
Host: Rabbit Polyclonal
BID Antibody [Unconjugated]
BID Antibody [Unconjugated]
AF860
Species: Hu, Mu
Applications: WB, Simple Western, IP
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
BID Antibody
BID Antibody
AF846
Species: Hu
Applications: WB
Host: Rabbit Polyclonal
Antibody Pairs
BID Antibody Pair
BID Antibody Pair
H00000637-AP12
Species: Hu
Applications: S-ELISA
BID Antibody Pair
BID Antibody Pair
H00000637-AP11
Species: Hu
Applications: S-ELISA
Lysates
BID Overexpression Lysate (Na ...
BID Overexpression Lysate (Native)
NBP2-04747
Applications: WB
BID Overexpression Lysate (Na ...
BID Overexpression Lysate (Native)
NBP2-10076
Applications: WB
BID Overexpression Lysate (Na ...
BID Overexpression Lysate (Native)
NBL1-07979
Applications: WB
Proteins
Recombinant Human BID Protein ...
Recombinant Human BID Protein
H00000637-P01
Species: Hu
Applications: WB, ELISA, PA
BID Recombinant Protein Antig ...
BID Recombinant Protein Antigen
NBP1-86187PEP
Species: Hu
Applications: AC
Recombinant Human BID Protein ...
Recombinant Human BID Protein
NBC1-18512
Species: Hu
Applications: PAGE
RNAi
BID RNAi
BID RNAi
H00000637-R01
Species: Hu
Applications: RNAi, RNAi SP
BID RNAi
BID RNAi
H00000637-R03
Species: Hu
Applications: RNAi, RNAi SP
BID RNAi
BID RNAi
H00000637-R02
Species: Hu
Applications: RNAi, RNAi SP

Description

The Bcl-2 family of apoptosis-related genes plays central roles in regulating apoptotic pathways (reviewed in Thomadaki and Scorilas, 2006). Regulation of cell death through apoptosis is critical for the maintenance of homeostasis, defense against infectious agents, and normal development. Bcl-2 family proteins regulate apoptosis primarily through the regulation of mitochondrial outer membrane permeability. In mammals, the family consists of both prosurvival (antiapoptotic) and proapoptotic (prodeath) members. Cellular homeostasis is thought to be dependent on a balance between the actions of prosurvival and proapoptotic proteins. Bcl-2 family proteins can be divided into 3 main subfamilies on the basis of their function and the content of their Bcl-2 homology (BH) domains, for example: 1) Prosurvival: Bcl-2, Bcl-XL, Bcl-W, A1, and Mcl-1 2) Proapoptotic (multidomain): Bax, Bak, and Bok. 3) BH3-only (proapoptotic): Bad, Bcl-XS, Bid, Bik, Bim, Blk, Bmf, Bnip, Noxa, and Puma. Prosurvival members inhibit cells from undergoing apoptosis, whereas proapoptotic and BH3-only subfamily members promote apoptosis. There are 4 BH domains (1-4) conserved among Bcl-2 family proteins. The BH domains are important for function as well as for heterodimerization between family members. Typical prosurvival family members have all four BH domains (1-4), whereas proapoptotic (multidomain) members have BH1, 2 and 3 domains and BH3-only members have only the BH3 domain. Overall, the relative ratio of prosurvival and proapoptotic proteins determines the suseptibility of a cell to various apoptotic stimuli. Many Bcl-2 family proteins are differentially expressed in various malignancies and some are useful prognostic biomarkers. Prosurvival proteins are often elevated in diverse cancers and have the potential to confer resistance to both endogenous cell death stimuli and cancer treatments. Alterations in the ratio or levels of Bcl-2 family proteins have been also associated with nonmalignant diseases including neurodegenerative diseases, autoimmune diseases, AIDs, Down's syndrome, cardiovascular diseases, diabetes, glomerulonephritis, and muscular dystrophy. IMG-5693 recognizes Bid (approx. 19-23 kDa) and cleaved/truncated forms of Bid. The C-terminal cleaved/truncated form (11-15 kDa) of Bid is often referred to as tBid in the literature (reviewed in Yin, 2006).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Human
Human
Human
Human
Human
Human
Human
Human
Mouse
Mouse
Product By Gene ID 637
Alternate Names
  • apoptic death agonist
  • Human BID coding sequence
  • desmocollin type 4
  • MGC42355
  • BID isoform Si6
  • MGC15319
  • BID isoform L(2)
  • FP497
  • BID isoform ES(1b)
  • p22 BID
  • BH3-interacting domain death agonist
  • BH3 interacting domain death agonist

Research Areas for BID

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Phospho-Specific
Tumor Suppressors

Bioinformatics Tool for BID

Discover related pathways, diseases and genes to BID. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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Related BID Blog Posts

Check out the latest blog posts on BID.
Apoptosis and Necroptosis Part I: Important factors to identify both types of programmed cell death
Different types of cell death have classically been identified by discrete morphological changes. The hallmarks of apoptosis include cell shrinkage, nuclear fragmentation and membrane blebbing whereas necroptosis is characterized by cell swelling...    Read more.
The use of apoptosis antibodies and controls in cell death research
Apoptosis is a method of programmed cell death that is notably characterized by a morphological change in cellular nuclei and membrane appearance.  Not to be confused with necrosis, apoptosis is a pathway that is induced by a variety of factors tha...    Read more.
The role of p53 in UV radiation DNA damage and subsequent tumorogenesis
p53, the protein product of the tp53 gene, is one of the most widely studied tumor suppressor proteins in cancer research.  p53 is unique in that it demonstrates both tumor suppressive and tumor progressive properties depending on whether it is fu...    Read more.
active/cleaved Caspase 2 - Inducing apoptosis in response to cellular stress
Caspase-2 is a highly conserved member of the caspase family involved in the initiation and execution of apoptosis. While its function is still poorly understood, caspase-2 is thought to be important for apoptosis in response to DNA damage, bacteri...    Read more.
Bcl-2 - an antiapoptotic protein with an important role in cancer cell survival
B-cell lymphoma 2 (Bcl-2) protein is an oncogene that normally acts as an apoptotic inhibitor and localizes to the mitochondrial membrane where it prevents the release of cytochrome c. The Bcl-2 protein family consists of over 20 proteins each co...    Read more.
Read more BID related blogs.