Bestrophin 1 Products

Bestrophin 1 Antibody
Bestrophin 1 Antibody
Species: Hu, Mu, Rt
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
Bestrophin 1 Antibody
Bestrophin 1 Antibody
Species: Hu, Mu
Applications: WB, ICC/IF
Host: Rabbit Polyclonal
Bestrophin 1 293T Cell Transi ...
Bestrophin 1 293T Cell Transient O...
Species: Hu
Applications: WB
Recombinant Human Bestrophin ...
Recombinant Human Bestrophin 1 His...
Species: Hu
Applications: PAGE
Bestrophin 1 Recombinant Prot ...
Bestrophin 1 Recombinant Protein A...
Species: Hu
Applications: AC


Bestrophin 1 (BEST1) is a member of the bestrophin family of anion channels. Bestrophins are transmembrane (TM) proteins that share a homology region containing a high content of aromatic residues, including an invariant arg-phe-pro (RFP) motif. Bestrophins are believed to function as chloride channels.

Bestrophin-1, also known as best macular dystrophy (BMD) or vitelliform macular dystrophy (VMD2), is an inherited autosomal form of macular degeneration, characterized by a depressed light peak in the electrooculogram (EOG). Bestrophin 1 is a 68 kDa basolateral plasma membrane protein encoded by the VMD2 gene. Bestrophin 1's function is still unknown, but data suggests that it is a chloride channel that plays a role in generating the altered EOG in Best disease patients. In addition, Bestrophin-1 is a useful biochemical and histological marker of RPE (retinal pigment epithelial cells) cells.

Bestrophin antibodies are useful tools for studies involving vision and retinal disease. .


Entrez Human
Uniprot Human
Product By Gene ID 7439
Alternate Names
  • TU15B
  • bestrophin-1
  • Vitelliform macular dystrophy protein 2
  • Best disease
  • BMD
  • vitelliform macular dystrophy 2
  • BEST
  • VMD2RP50
  • ARB
  • bestrophin 1

Research Areas for Bestrophin 1

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Sensory Systems

PTMs for Bestrophin 1

Learn more about PTMs related to Bestrophin 1.


Bioinformatics Tool for Bestrophin 1

Discover related pathways, diseases and genes to Bestrophin 1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Vizit™, under license from BioVista Inc.

Related Bestrophin 1 Blog Posts

Check out the latest blog posts on Bestrophin 1.
Vision Infographic: Do you see how I see?
Vision involves several parts of the eye processing light which send signals to the brain via the optic nerve to process information. Learn more about the vision process and related ocular proteins in the infographic below. Novus Biological...    Read more.
Bestrophin 1: Implications in Progressive Vision Loss
The human Bestrophin family has four members, Best1, Best2, Best3 and Best4. These transmembrane proteins can function as chloride channels, and can also regulate calcium channels (1). The Bestrophins all have a conserved domain which begins at the N-...    Read more.
"I can see clearly now": Targeting Bestrophin 1 to treat Bestrophinopathies
Encoded by the VMD2 gene on chromosome 11q13 Bestrophin 1 is the prototypic member of the RFP family of proteins which are more commonly called "bestrophins". The protein family was originally identified in Caenorhabditis elegans based on a conserved...    Read more.
Read more Bestrophin 1 related blogs.