Bestrophin 1 Products

Antibodies
Bestrophin 1 Antibody (E6-6)
Bestrophin 1 Antibody (E6-6)
NB300-164
Species: Hu, Ca, Rt(-), Primate, Porcine
Applications: WB, ICC/IF, IHC-Fr, IHC-P, IP
Host: Mouse Monoclonal
Bestrophin 1 Antibody (1C2)
Bestrophin 1 Antibody (1C2)
H00007439-M01
Species: Hu
Applications: WB, ELISA
Host: Mouse Monoclonal
Bestrophin 1 Antibody
Bestrophin 1 Antibody
H00007439-B01P
Species: Hu
Applications: WB, ELISA
Host: Mouse Polyclonal
Lysates
Bestrophin 1 Overexpression L ...
Bestrophin 1 Overexpression Lysate...
H00007439-T01
Species: Hu
Applications: WB
Proteins
Bestrophin 1 Partial Recombin ...
Bestrophin 1 Partial Recombinant P...
H00007439-Q01
Species: Hu
Applications: WB, ELISA, PA
Bestrophin 1 Recombinant Prot ...
Bestrophin 1 Recombinant Protein
H00007439-P01
Species: Hu
Applications: WB, ELISA, PA
Bestrophin 1 Recombinant Prot ...
Bestrophin 1 Recombinant Protein
NBP2-53038
Species: Hu
Applications: PAGE
RNAi
Bestrophin 1 RNAi
Bestrophin 1 RNAi
H00007439-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

Bestrophin 1 (BEST1) is a member of the bestrophin family of anion channels. Bestrophins are transmembrane (TM) proteins that share a homology region containing a high content of aromatic residues, including an invariant arg-phe-pro (RFP) motif. Bestrophins are believed to function as chloride channels.

Bestrophin-1, also known as best macular dystrophy (BMD) or vitelliform macular dystrophy (VMD2), is an inherited autosomal form of macular degeneration, characterized by a depressed light peak in the electrooculogram (EOG). Bestrophin 1 is a 68 kDa basolateral plasma membrane protein encoded by the VMD2 gene. Bestrophin 1's function is still unknown, but data suggests that it is a chloride channel that plays a role in generating the altered EOG in Best disease patients. In addition, Bestrophin-1 is a useful biochemical and histological marker of RPE (retinal pigment epithelial cells) cells.

Bestrophin antibodies are useful tools for studies involving vision and retinal disease. .

Bioinformatics

Entrez Human
Rat
Uniprot Human
Human
Human
Product By Gene ID 7439
Alternate Names
  • TU15B
  • bestrophin-1
  • Vitelliform macular dystrophy protein 2
  • Best disease
  • BMD
  • vitelliform macular dystrophy 2
  • BEST
  • VMD2RP50
  • ARB
  • bestrophin 1

Research Areas for Bestrophin 1

Find related products by research area and learn more about each of the different research areas below.

Neuroscience
Sensory Systems
Vision

PTMs for Bestrophin 1

Learn more about PTMs related to Bestrophin 1.

Phosphorylation
Dephosphorylation
Biotinylation

Bioinformatics Tool for Bestrophin 1

Discover related pathways, diseases and genes to Bestrophin 1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related Bestrophin 1 Blog Posts

Check out the latest blog posts on Bestrophin 1.
Vision Infographic: Do you see how I see?
Vision involves several parts of the eye processing light which send signals to the brain via the optic nerve to process information. Learn more about the vision process and related ocular proteins in the infographic below. Novus Biological...    Read more.
Bestrophin 1: Implications in Progressive Vision Loss
The human Bestrophin family has four members, Best1, Best2, Best3 and Best4. These transmembrane proteins can function as chloride channels, and can also regulate calcium channels (1). The Bestrophins all have a conserved domain which begins at the N-...    Read more.
"I can see clearly now": Targeting Bestrophin 1 to treat Bestrophinopathies
Encoded by the VMD2 gene on chromosome 11q13 Bestrophin 1 is the prototypic member of the RFP family of proteins which are more commonly called "bestrophins". The protein family was originally identified in Caenorhabditis elegans based on a conserved...    Read more.
Read more Bestrophin 1 related blogs.