BAF53A Products

Description

BAF53A encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described.

Bioinformatics

Entrez	51412 Human 56456 Mouse 86 Human
Uniprot	AAH00949 Human NM_004301 Human NM_177989 Human NP_004292 Human NP_004292.1 Human NP_057272 Human NP_057272 Human NP_817126 Human NP_829888 Human NP004292 Human O96019 Human
Product By Gene ID	86
Alternate Names	actin-like 6A actin-like protein 6A actin-related protein 4,53 kDa BRG1-associated factor A Actin-related protein Baf53a Actl6 Arp4 ArpNbeta arpNbeta BAF complex 53 kDa subunit Baf53a BAF53AACTL6 BAF53MGC5382 BRG1-associated factor 53A hArpN beta INO80 complex subunit K INO80KARPN-BETA

Diseases related to BAF53A

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Neoplasms
Retinoblastoma
Cell Transformation, Neoplastic
Congenital Abnormality
Pediatric Neoplasm
Rhabdomyosarcoma
Nerve Degeneration
Uterine Cervical Neoplasm
Spina Bifida
Kidney Neoplasm
Malignant Tumor Of Cervix
Nephroblastoma
Carcinoma
Carcinogenesis
Immunologic Deficiency Syndromes
Rhabdoid Tumor
Malignant Neoplasms
Hiv Infections

Pathways for BAF53A

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Chromatin Remodeling
Atp-dependent Chromatin Remodeling
Cell Proliferation
Gene Silencing
Regulation Of Gene Expression
Localization
Histone H4 Acetylation
Viral Transcription
Spindle Checkpoint
Cell Death
Cell Growth
Chromosome Condensation
Viral Replication
Apoptotic Process
Lymphocyte Activation

Research Areas for BAF53A

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Extracellular Matrix

PTMs for BAF53A

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Acetylation
Phosphorylation

Bioinformatics Tool for BAF53A

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