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AIRE encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CBP. At least three splice variant mRNAs products have been described including one which results in a premature stop codon and a transcript predicted to be a candidate for nuclear-mediated decay (NMD). Defects in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
![Western Blot Autoimmune Regulator/AIRE Antibody (609930) [Unconjugated]](http://images.novusbio.com/fullsize/antibody/Autoimmune_Regulator_MAB6184_Western_Blot_10455.jpg)
![Intracellular Staining by Flow Cytometry Autoimmune Regulator/AIRE Antibody (609930) [Unconjugated]](http://images.novusbio.com/fullsize/antibody/Autoimmune_Regulator_MAB6184_Flow_Cytometry_11942.jpg)
