ATP6V1A Products

Description

ATP6V1A encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain A subunit isoforms and is found in all tissues. Transcript variants derived from alternative polyadenylation exist. [provided by RefSeq]

Bioinformatics

Entrez	523 Human
Uniprot	AAH13138 Human NM_001690 Human NP_001681 Human P38606 Human
Product By Gene ID	523
Alternate Names	70kD, isoform 1 ATP6A1 ATP6V1A1ATPase, H+ transporting, lysosomal, subunit A1 ATPase, H+ transporting, lysosomal (vacuolar proton pump), alpha polypeptide ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A EC 3.6.3 EC 3.6.3.14 H(+)-transporting two-sector ATPase, subunit A H+-transporting ATPase chain A, vacuolar (VA68 type) HO68 VA68 vacuolar ATP synthase catalytic subunit A, ubiquitous isoform Vacuolar ATPase isoform VA68 vacuolar proton pump alpha subunit 1 Vacuolar proton pump subunit alpha V-ATPase 69 kDa subunit 1 V-ATPase 69 kDa subunit V-ATPase A subunit 1 V-ATPase subunit A Vma1 VPP2 V-type proton ATPase catalytic subunit A