ATP6V0A1 Products

Description

ATP6V0A1 encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three A subunit proteins and the encoded protein is associated with clathrin-coated vesicles. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Bioinformatics

Entrez	535 Human
Uniprot	NP_005168 Human NP_005168.2 Human Q93050 Human
Product By Gene ID	535
Alternate Names	a1 ATP6N1 ATP6N1AATPase, H+ transporting, lysosomal non-catalytic accessory protein 1(110/116kD) ATP6V0 ATPase, H+ transporting, lysosomal (vacuolar proton pump) non-catalyticaccessory protein 1A (110/116kD) ATPase, H+ transporting, lysosomal V0 subunit a isoform 1 ATPase, H+ transporting, lysosomal V0 subunit a1 Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit DKFZp781J1951 Stv1 Vacuolar adenosine triphosphatase subunit Ac116 Vacuolar proton pump subunit 1 vacuolar proton pump, subunit 1 Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1 vacuolar proton translocating ATPase 116 kDa subunit A vacuolar-type H(+)-ATPase 115 kDa subunit V-ATPase 116 kDa isoform a1 V-ATPase 116 kDa Vph1 VPP1H(+)-transporting two-sector ATPase, 116 kDa accessory protein A1 V-type proton ATPase 116 kDa subunit a isoform 1 V-type proton ATPase 116 kDa subunit a